Synthesis and Characterization of Impurities in the Production Process of Lopinavir

Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of...

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Autores principales: Raghava Reddy, Ambati V., Garaga, Srinivas, Takshinamoorthy, Chandiran, Naidu, Andra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727799/
https://www.ncbi.nlm.nih.gov/pubmed/26839801
http://dx.doi.org/10.3797/scipharm.1407-14
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author Raghava Reddy, Ambati V.
Garaga, Srinivas
Takshinamoorthy, Chandiran
Naidu, Andra
author_facet Raghava Reddy, Ambati V.
Garaga, Srinivas
Takshinamoorthy, Chandiran
Naidu, Andra
author_sort Raghava Reddy, Ambati V.
collection PubMed
description Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances.
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spelling pubmed-47277992016-02-02 Synthesis and Characterization of Impurities in the Production Process of Lopinavir Raghava Reddy, Ambati V. Garaga, Srinivas Takshinamoorthy, Chandiran Naidu, Andra Sci Pharm Research Article Lopinavir is an antiretroviral drug used for the inhibition of HIV protease. Four related substances of lopinavir were observed during the manufacturing process of lopinavir in the laboratory and they were identified. The present work describes the origin, synthesis, characterization, and control of these related substances. The Austrian Journal of Pharmaceutical Sciences 2015 2014-09-22 /pmc/articles/PMC4727799/ /pubmed/26839801 http://dx.doi.org/10.3797/scipharm.1407-14 Text en Copyright: © Raghava Reddy et al. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Raghava Reddy, Ambati V.
Garaga, Srinivas
Takshinamoorthy, Chandiran
Naidu, Andra
Synthesis and Characterization of Impurities in the Production Process of Lopinavir
title Synthesis and Characterization of Impurities in the Production Process of Lopinavir
title_full Synthesis and Characterization of Impurities in the Production Process of Lopinavir
title_fullStr Synthesis and Characterization of Impurities in the Production Process of Lopinavir
title_full_unstemmed Synthesis and Characterization of Impurities in the Production Process of Lopinavir
title_short Synthesis and Characterization of Impurities in the Production Process of Lopinavir
title_sort synthesis and characterization of impurities in the production process of lopinavir
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727799/
https://www.ncbi.nlm.nih.gov/pubmed/26839801
http://dx.doi.org/10.3797/scipharm.1407-14
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AT takshinamoorthychandiran synthesisandcharacterizationofimpuritiesintheproductionprocessoflopinavir
AT naiduandra synthesisandcharacterizationofimpuritiesintheproductionprocessoflopinavir

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