One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4(+) T Cells, and IL-17A

A rapidly acting, single dose vaccine against Staphylococcus aureus would be highly beneficial for patients scheduled for major surgeries or in intensive care units. Here we show that one immunization with a multicomponent S. aureus candidate vaccine, 4C-Staph, formulated with a novel TLR7-dependent...

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Detalles Bibliográficos
Autores principales: Mancini, Francesca, Monaci, Elisabetta, Lofano, Giuseppe, Torre, Antonina, Bacconi, Marta, Tavarini, Simona, Sammicheli, Chiara, Arcidiacono, Letizia, Galletti, Bruno, Laera, Donatello, Pallaoro, Michele, Tuscano, Giovanna, Fontana, Maria Rita, Bensi, Giuliano, Grandi, Guido, Rossi-Paccani, Silvia, Nuti, Sandra, Rappuoli, Rino, De Gregorio, Ennio, Bagnoli, Fabio, Soldaini, Elisabetta, Bertholet, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727907/
https://www.ncbi.nlm.nih.gov/pubmed/26812180
http://dx.doi.org/10.1371/journal.pone.0147767

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