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Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth

The Drosophila mutant tko(25t) exhibits a deficiency of mitochondrial protein synthesis, leading to a global insufficiency of respiration and oxidative phosphorylation. This entrains an organismal phenotype of developmental delay and sensitivity to seizures induced by mechanical stress. We found tha...

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Detalles Bibliográficos
Autores principales: Kemppainen, Esko, George, Jack, Garipler, Görkem, Tuomela, Tea, Kiviranta, Essi, Soga, Tomoyoshi, Dunn, Cory D., Jacobs, Howard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728084/
https://www.ncbi.nlm.nih.gov/pubmed/26812173
http://dx.doi.org/10.1371/journal.pone.0145836