Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines

Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemic...

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Detalles Bibliográficos
Autores principales: Jiang, Shibo, Li, Runming, Du, Lanying, Liu, Shuwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728157/
https://www.ncbi.nlm.nih.gov/pubmed/21203946
http://dx.doi.org/10.1007/s13238-010-0054-6
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author Jiang, Shibo
Li, Runming
Du, Lanying
Liu, Shuwen
author_facet Jiang, Shibo
Li, Runming
Du, Lanying
Liu, Shuwen
author_sort Jiang, Shibo
collection PubMed
description Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics. Hemagglutinin (HA) of IAV plays a critical role in viral binding, fusion and entry, and contains the major neutralizing epitopes. Therefore, HA is an attractive target for developing anti-IAV drugs and vaccines. Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.
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spelling pubmed-47281572016-01-28 Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines Jiang, Shibo Li, Runming Du, Lanying Liu, Shuwen Protein Cell Review Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics. Hemagglutinin (HA) of IAV plays a critical role in viral binding, fusion and entry, and contains the major neutralizing epitopes. Therefore, HA is an attractive target for developing anti-IAV drugs and vaccines. Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines. Higher Education Press 2010-04-01 2010-04 /pmc/articles/PMC4728157/ /pubmed/21203946 http://dx.doi.org/10.1007/s13238-010-0054-6 Text en © Higher Education Press and Springer-Verlag Berlin Heidelberg 2010
spellingShingle Review
Jiang, Shibo
Li, Runming
Du, Lanying
Liu, Shuwen
Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines
title Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines
title_full Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines
title_fullStr Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines
title_full_unstemmed Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines
title_short Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines
title_sort roles of the hemagglutinin of influenza a virus in viral entry and development of antiviral therapeutics and vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728157/
https://www.ncbi.nlm.nih.gov/pubmed/21203946
http://dx.doi.org/10.1007/s13238-010-0054-6
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AT dulanying rolesofthehemagglutininofinfluenzaavirusinviralentryanddevelopmentofantiviraltherapeuticsandvaccines
AT liushuwen rolesofthehemagglutininofinfluenzaavirusinviralentryanddevelopmentofantiviraltherapeuticsandvaccines

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