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The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA
The MHC class I chain-related molecule A (MICA) is a ligand for the activating natural killer (NK) cell receptor NKG2D. A polymorphism causing a valine to methionine exchange at position 129 affects binding to NKG2D, cytotoxicity, interferon-γ release by NK cells and activation of CD8(+) T cells. It...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728179/ https://www.ncbi.nlm.nih.gov/pubmed/26585323 http://dx.doi.org/10.1007/s00251-015-0884-8 |