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A fluorescent approach for identifying P2X1 ligands

There are no commercially available, small, receptor-specific P2X1 ligands. There are several synthetic derivatives of the natural agonist ATP and some structurally-complex antagonists including compounds such as PPADS, NTP-ATP, suramin and its derivatives (e.g. NF279, NF449). NF449 is the most pote...

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Detalles Bibliográficos
Autores principales:	Ruepp, Marc-David, Brozik, James A., de Esch, Iwan J.P., Farndale, Richard W., Murrell-Lagnado, Ruth D., Thompson, Andrew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Pergamon Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728187/ https://www.ncbi.nlm.nih.gov/pubmed/26026951 http://dx.doi.org/10.1016/j.neuropharm.2015.05.016

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