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Human skin dendritic cells in health and disease

Dendritic cells (DCs) are specialized antigen presenting cells abundant in peripheral tissues such as skin where they function as immune sentinels. Skin DCs migrate to draining lymph node where they interact with naïve T cells to induce immune responses to microorganisms, vaccines, tumours and self-...

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Detalles Bibliográficos
Autores principales: Haniffa, Muzlifah, Gunawan, Merry, Jardine, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728191/
https://www.ncbi.nlm.nih.gov/pubmed/25301671
http://dx.doi.org/10.1016/j.jdermsci.2014.08.012
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author Haniffa, Muzlifah
Gunawan, Merry
Jardine, Laura
author_facet Haniffa, Muzlifah
Gunawan, Merry
Jardine, Laura
author_sort Haniffa, Muzlifah
collection PubMed
description Dendritic cells (DCs) are specialized antigen presenting cells abundant in peripheral tissues such as skin where they function as immune sentinels. Skin DCs migrate to draining lymph node where they interact with naïve T cells to induce immune responses to microorganisms, vaccines, tumours and self-antigens. In this review, we present the key historical developments and recent advances in human skin DC research. We also integrate the current understanding on the origin and functional specializations of DC subsets in healthy skin with findings in inflammatory skin diseases focusing on psoriasis and atopic eczema. A comprehensive understanding of the dynamic changes in DC subsets in health and disease will form a strong foundation to facilitate the clinical translation of DC-based therapeutic and vaccination strategies.
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spelling pubmed-47281912016-02-22 Human skin dendritic cells in health and disease Haniffa, Muzlifah Gunawan, Merry Jardine, Laura J Dermatol Sci Invited Review Article Dendritic cells (DCs) are specialized antigen presenting cells abundant in peripheral tissues such as skin where they function as immune sentinels. Skin DCs migrate to draining lymph node where they interact with naïve T cells to induce immune responses to microorganisms, vaccines, tumours and self-antigens. In this review, we present the key historical developments and recent advances in human skin DC research. We also integrate the current understanding on the origin and functional specializations of DC subsets in healthy skin with findings in inflammatory skin diseases focusing on psoriasis and atopic eczema. A comprehensive understanding of the dynamic changes in DC subsets in health and disease will form a strong foundation to facilitate the clinical translation of DC-based therapeutic and vaccination strategies. Elsevier 2015-02 /pmc/articles/PMC4728191/ /pubmed/25301671 http://dx.doi.org/10.1016/j.jdermsci.2014.08.012 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Invited Review Article
Haniffa, Muzlifah
Gunawan, Merry
Jardine, Laura
Human skin dendritic cells in health and disease
title Human skin dendritic cells in health and disease
title_full Human skin dendritic cells in health and disease
title_fullStr Human skin dendritic cells in health and disease
title_full_unstemmed Human skin dendritic cells in health and disease
title_short Human skin dendritic cells in health and disease
title_sort human skin dendritic cells in health and disease
topic Invited Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728191/
https://www.ncbi.nlm.nih.gov/pubmed/25301671
http://dx.doi.org/10.1016/j.jdermsci.2014.08.012
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