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Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase plays a major role in mitosis and emerging evidence indicates that PLK1 is also i...

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Detalles Bibliográficos
Autores principales:	O'Connor, Aisling, Maffini, Stefano, Rainey, Michael D., Kaczmarczyk, Agnieszka, Gaboriau, David, Musacchio, Andrea, Santocanale, Corrado
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728306/ https://www.ncbi.nlm.nih.gov/pubmed/26685311 http://dx.doi.org/10.1242/bio.014969

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