The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders

The deleterious effects of a disrupted copper metabolism are illustrated by hereditary diseases caused by mutations in the genes coding for the copper transporters ATP7A and ATP7B. Menkes disease, involving ATP7A, is a fatal neurodegenerative disorder of copper deficiency. Mutations in ATP7B lead to...

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Detalles Bibliográficos
Autores principales: Fieten, Hille, Gill, Yadvinder, Martin, Alan J., Concilli, Mafalda, Dirksen, Karen, van Steenbeek, Frank G., Spee, Bart, van den Ingh, Ted S. G. A. M., Martens, Ellen C. C. P., Festa, Paola, Chesi, Giancarlo, van de Sluis, Bart, Houwen, Roderick H. J. H., Watson, Adrian L., Aulchenko, Yurii S., Hodgkinson, Victoria L., Zhu, Sha, Petris, Michael J., Polishchuk, Roman S., Leegwater, Peter A. J., Rothuizen, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728329/
https://www.ncbi.nlm.nih.gov/pubmed/26747866
http://dx.doi.org/10.1242/dmm.020263

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