APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the main factors causing mutations in human cancers. APOBEC deaminates cytosines in single-stranded DNA (ssDNA). A fraction of the APOBEC-induced mutations occur as clusters (“kataegis”) in single-stranded DNA produced during...

Descripción completa

Detalles Bibliográficos
Autores principales: Seplyarskiy, Vladimir B., Soldatov, Ruslan A., Popadin, Konstantin Y., Antonarakis, Stylianos E., Bazykin, Georgii A., Nikolaev, Sergey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728370/
https://www.ncbi.nlm.nih.gov/pubmed/26755635
http://dx.doi.org/10.1101/gr.197046.115

Ejemplares similares

Ejemplares similares