BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis

c-MYC oncogene is deregulated in most human tumours. Histone marks associated with transcriptionally active genes define high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are unknown. Here we report that c-MYC interacts with BPTF, a core subunit of the NURF chromatin...

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Detalles Bibliográficos
Autores principales: Richart, Laia, Carrillo-de Santa Pau, Enrique, Río-Machín, Ana, de Andrés, Mónica P., Cigudosa, Juan C., Lobo, Víctor J. Sánchez-Arévalo, Real, Francisco X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728380/
https://www.ncbi.nlm.nih.gov/pubmed/26729287
http://dx.doi.org/10.1038/ncomms10153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728380/
https://www.ncbi.nlm.nih.gov/pubmed/26729287
http://dx.doi.org/10.1038/ncomms10153

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