Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker

BACKGROUND AND PURPOSE: Calcium‐activated chloride channels (CaCCs) play varied physiological roles and constitute potential therapeutic targets for conditions such as asthma and hypertension. TMEM16A encodes a CaCC. CaCC pharmacology is restricted to compounds with relatively low potency and poorly...

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Detalles Bibliográficos
Autores principales: Ta, Chau M, Adomaviciene, Aiste, Rorsman, Nils J G, Garnett, Hannah, Tammaro, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728427/
https://www.ncbi.nlm.nih.gov/pubmed/26562072
http://dx.doi.org/10.1111/bph.13381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728427/
https://www.ncbi.nlm.nih.gov/pubmed/26562072
http://dx.doi.org/10.1111/bph.13381

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