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Mechanism of allosteric activation of TMEM16A/ANO1 channels by a commonly used chloride channel blocker
BACKGROUND AND PURPOSE: Calcium‐activated chloride channels (CaCCs) play varied physiological roles and constitute potential therapeutic targets for conditions such as asthma and hypertension. TMEM16A encodes a CaCC. CaCC pharmacology is restricted to compounds with relatively low potency and poorly...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728427/ https://www.ncbi.nlm.nih.gov/pubmed/26562072 http://dx.doi.org/10.1111/bph.13381 |