APT070 (mirococept), a membrane‐localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model

BACKGROUND AND PURPOSE: A major obstacle to islet cell transplantation is the early loss of transplanted islets resulting from the instant blood‐mediated inflammation reaction (IBMIR). The activation of complement pathways plays a central role in IBMIR. The aim of this study was to test the inhibito...

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Detalles Bibliográficos
Autores principales: Xiao, Fang, Ma, Liang, Zhao, Min, Smith, Richard A, Huang, Guocai, Jones, Peter M, Persaud, Shanta, Pingitore, Attilio, Dorling, Anthony, Lechler, Robert, Lombardi, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728428/
https://www.ncbi.nlm.nih.gov/pubmed/26565566
http://dx.doi.org/10.1111/bph.13388

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