DCAF1 controls T-cell function via p53-dependent and -independent mechanisms

On activation, naive T cells grow in size and enter cell cycle to mount immune response. How the fundamental processes of T-cell growth and cell cycle entry are regulated is poorly understood. Here we report that DCAF1 (Ddb1–cullin4-associated-factor 1) is essential for these processes. The deletion...

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Detalles Bibliográficos
Autores principales: Guo, Zengli, Kong, Qing, Liu, Cui, Zhang, Song, Zou, Liyun, Yan, Feng, Whitmire, Jason K., Xiong, Yue, Chen, Xian, Wan, Yisong Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728445/
https://www.ncbi.nlm.nih.gov/pubmed/26728942
http://dx.doi.org/10.1038/ncomms10307

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