Cargando…

Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects

Endoglin overexpression is associated with highly proliferative tumor endothelium and also with some tumors, including melanoma. Its targeting has anti-tumor effectiveness, which can also be obtained by RNA interference. The aim of our study was to explore the anti-tumor effectiveness of endoglin si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dolinsek, Tanja, Sersa, Gregor, Prosen, Lara, Bosnjak, Masa, Stimac, Monika, Razborsek, Urska, Cemazar, Maja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728450/ https://www.ncbi.nlm.nih.gov/pubmed/26712792 http://dx.doi.org/10.3390/cancers8010003

Ejemplares similares

Gene Electrotransfer of Plasmid with Tissue Specific Promoter Encoding shRNA against Endoglin Exerts Antitumor Efficacy against Murine TS/A Tumors by Vascular Targeted Effects
por: Stimac, Monika, et al.
Publicado: (2015)

Intratumoral Gene Electrotransfer of Plasmid DNA Encoding shRNA against Melanoma Cell Adhesion Molecule Radiosensitizes Tumors by Antivascular Effects and Activation of an Immune Response
por: Kranjc Brezar, Simona, et al.
Publicado: (2020)

Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity
por: Sedlar, Ales, et al.
Publicado: (2012)

Electrotransfer parameters as a tool for controlled and targeted gene expression in skin
por: Kos, Spela, et al.
Publicado: (2016)

Tumor Radiosensitization by Gene Electrotransfer-Mediated Double Targeting of Tumor Vasculature
por: Savarin, Monika, et al.
Publicado: (2023)

Electrotransfer of Different Control Plasmids Elicits Different Antitumor Effectiveness in B16.F10 Melanoma
por: Bosnjak, Masa, et al.
Publicado: (2018)

Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer
por: Sersa, Gregor, et al.
Publicado: (2015)

Multiple Delivery of siRNA against Endoglin into Murine Mammary Adenocarcinoma Prevents Angiogenesis and Delays Tumor Growth
por: Dolinsek, Tanja, et al.
Publicado: (2013)

Development of Tumor Cell-Based Vaccine with IL-12 Gene Electrotransfer as Adjuvant
por: Remic, Tinkara, et al.
Publicado: (2020)

Evaluation of a Novel Plasmid for Simultaneous Gene Electrotransfer-Mediated Silencing of CD105 and CD146 in Combination with Irradiation
por: Savarin, Monika, et al.
Publicado: (2021)

Treatment of Skin Tumors with Intratumoral Interleukin 12 Gene Electrotransfer in the Head and Neck Region: A First-in-human Clinical Trial Protocol
por: Groselj, Ales, et al.
Publicado: (2022)

Tumor perfusion evaluation using dynamic contrast-enhanced ultrasound after electrochemotherapy and IL-12 plasmid electrotransfer in murine melanoma
por: Brloznik, Maja, et al.
Publicado: (2021)

Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
por: Savarin, Monika, et al.
Publicado: (2017)

Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma
por: Sedlar, Ales, et al.
Publicado: (2013)

Tumor cell death after electrotransfer of plasmid DNA is associated with cytosolic DNA sensor upregulation
por: Znidar, Katarina, et al.
Publicado: (2018)

Gene Immunotherapy of Colon Carcinoma with IL-2 and IL-12 Using Gene Electrotransfer
por: Komel, Tilen, et al.
Publicado: (2023)

Cytosolic DNA Sensor Upregulation Accompanies DNA Electrotransfer in B16.F10 Melanoma Cells
por: Znidar, Katarina, et al.
Publicado: (2016)

Antitumor in situ vaccination effect of TNFα and IL-12 plasmid DNA electrotransfer in a murine melanoma model
por: Kamensek, Urska, et al.
Publicado: (2018)

The effectiveness of calcium electroporation combined with gene electrotransfer of a plasmid encoding IL-12 is tumor type-dependent
por: Lisec, Barbara, et al.
Publicado: (2023)

Upregulation of DNA Sensors in B16.F10 Melanoma Spheroid Cells After Electrotransfer of pDNA
por: Znidar, Katarina, et al.
Publicado: (2018)

Maintenance and gene electrotransfer efficiency of antibiotic resistance gene-free plasmids encoding mouse, canine and human interleukin-12 orthologues
por: Kamensek, Urska, et al.
Publicado: (2022)

Electrochemotherapy with bleomycin is effective in BRAF mutated melanoma cells and interacts with BRAF inhibitors
por: Dolinsek, Tanja, et al.
Publicado: (2016)

Biologically responsive carrier-mediated anti-angiogenesis shRNA delivery for tumor treatment
por: Che, Junyi, et al.
Publicado: (2016)

Muscle gene electrotransfer is increased by the antioxidant tempol in mice
por: Markelc, B, et al.
Publicado: (2012)

Electrotransfer of siRNA to Silence Enhanced Green Fluorescent Protein in Tumor Mediated by a High Intensity Pulsed Electromagnetic Field
por: Kranjc Brezar, Simona, et al.
Publicado: (2020)

Role of Endoglin (CD105) in the Progression of Hepatocellular Carcinoma and Anti-Angiogenic Therapy
por: Kasprzak, Aldona, et al.
Publicado: (2018)

Mcam Silencing With RNA Interference Using Magnetofection has Antitumor Effect in Murine Melanoma
por: Prosen, Lara, et al.
Publicado: (2014)

Endoglin (CD105) and proliferation index in recurrent glioblastoma treated with anti-angiogenic therapy
por: Bastos, António G. P., et al.
Publicado: (2022)

Health‐related quality of life in dogs treated with electrochemotherapy and/or interleukin‐12 gene electrotransfer
por: Milevoj, Nina, et al.
Publicado: (2020)

Effects of Electrochemotherapy with Cisplatin and Peritumoral IL-12 Gene Electrotransfer on Canine Mast Cell Tumors: a Histopathologic and Immunohistochemical Study
por: Salvadori, Claudia, et al.
Publicado: (2017)

Gene Electrotransfer of Plasmid-Encoding IL-12 Recruits the M1 Macrophages and Antigen-Presenting Cells Inducing the Eradication of Aggressive B16F10 Murine Melanoma
por: Lampreht Tratar, Ursa, et al.
Publicado: (2017)

Expression of endoglin (CD105) in cervical cancer
por: Zijlmans, H J, et al.
Publicado: (2009)

Continuous endoglin (CD105) overexpression disrupts angiogenesis and facilitates tumor cell metastasis
por: Ollauri-Ibáñez, Claudia, et al.
Publicado: (2020)

Hot and Cold Tumors: Is Endoglin (CD105) a Potential Target for Vessel Normalization?
por: Ollauri-Ibáñez, Claudia, et al.
Publicado: (2021)

The General Explanation Method with NMR Spectroscopy Enables the Identification of Metabolite Profiles Specific for Normal and Tumor Cell Lines
por: Pečnik, Klemen, et al.
Publicado: (2018)

What We Learned about the Feasibility of Gene Electrotransfer for Vaccination on a Model of COVID-19 Vaccine
por: Kamensek, Urska, et al.
Publicado: (2023)

Protamine nanoparticles for improving shRNA-mediated anti-cancer effects
por: Liu, Ming, et al.
Publicado: (2015)

Intravital Monitoring of Vasculature After Targeted Gene Therapy Alone or Combined With Tumor Irradiation
por: Savarin, Monika, et al.
Publicado: (2018)

Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model
por: Kamensek, Urska, et al.
Publicado: (2013)

Evaluation of Endoglin (CD105) expression in pediatric rhabdomyosarcoma
por: Di Paolo, Virginia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_e48b4suqaqfiooer119n446uja