Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma

Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this re...

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Detalles Bibliográficos
Autores principales: Garner, Evan F., Beierle, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728452/
https://www.ncbi.nlm.nih.gov/pubmed/26729169
http://dx.doi.org/10.3390/cancers8010005
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author Garner, Evan F.
Beierle, Elizabeth A.
author_facet Garner, Evan F.
Beierle, Elizabeth A.
author_sort Garner, Evan F.
collection PubMed
description Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
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spelling pubmed-47284522016-02-08 Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma Garner, Evan F. Beierle, Elizabeth A. Cancers (Basel) Review Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease. MDPI 2015-12-31 /pmc/articles/PMC4728452/ /pubmed/26729169 http://dx.doi.org/10.3390/cancers8010005 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garner, Evan F.
Beierle, Elizabeth A.
Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_full Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_fullStr Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_full_unstemmed Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_short Cancer Stem Cells and Their Interaction with the Tumor Microenvironment in Neuroblastoma
title_sort cancer stem cells and their interaction with the tumor microenvironment in neuroblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728452/
https://www.ncbi.nlm.nih.gov/pubmed/26729169
http://dx.doi.org/10.3390/cancers8010005
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