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New Drugs from Marine Organisms in Alzheimer’s Disease
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Current approved drugs may only ameliorate symptoms in a restricted number of patients and for a restricted period of time. Currently, there is a translational research challenge into identifying the new effective drugs and the...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728502/ https://www.ncbi.nlm.nih.gov/pubmed/26712769 http://dx.doi.org/10.3390/md14010005 |
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author | Russo, Patrizia Kisialiou, Aliaksei Lamonaca, Palma Moroni, Rossana Prinzi, Giulia Fini, Massimo |
author_facet | Russo, Patrizia Kisialiou, Aliaksei Lamonaca, Palma Moroni, Rossana Prinzi, Giulia Fini, Massimo |
author_sort | Russo, Patrizia |
collection | PubMed |
description | Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Current approved drugs may only ameliorate symptoms in a restricted number of patients and for a restricted period of time. Currently, there is a translational research challenge into identifying the new effective drugs and their respective new therapeutic targets in AD and other neurodegenerative disorders. In this review, selected examples of marine-derived compounds in neurodegeneration, specifically in AD field are reported. The emphasis has been done on compounds and their possible relevant biological activities. The proposed drug development paradigm and current hypotheses should be accurately investigated in the future of AD therapy directions although taking into account successful examples of such approach represented by Cytarabine, Trabectedin, Eribulin and Ziconotide. We review a complexity of the translational research for such a development of new therapies for AD. Bryostatin is a prominent candidate for the therapy of AD and other types of dementia in humans. |
format | Online Article Text |
id | pubmed-4728502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47285022016-02-08 New Drugs from Marine Organisms in Alzheimer’s Disease Russo, Patrizia Kisialiou, Aliaksei Lamonaca, Palma Moroni, Rossana Prinzi, Giulia Fini, Massimo Mar Drugs Review Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Current approved drugs may only ameliorate symptoms in a restricted number of patients and for a restricted period of time. Currently, there is a translational research challenge into identifying the new effective drugs and their respective new therapeutic targets in AD and other neurodegenerative disorders. In this review, selected examples of marine-derived compounds in neurodegeneration, specifically in AD field are reported. The emphasis has been done on compounds and their possible relevant biological activities. The proposed drug development paradigm and current hypotheses should be accurately investigated in the future of AD therapy directions although taking into account successful examples of such approach represented by Cytarabine, Trabectedin, Eribulin and Ziconotide. We review a complexity of the translational research for such a development of new therapies for AD. Bryostatin is a prominent candidate for the therapy of AD and other types of dementia in humans. MDPI 2015-12-25 /pmc/articles/PMC4728502/ /pubmed/26712769 http://dx.doi.org/10.3390/md14010005 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Russo, Patrizia Kisialiou, Aliaksei Lamonaca, Palma Moroni, Rossana Prinzi, Giulia Fini, Massimo New Drugs from Marine Organisms in Alzheimer’s Disease |
title | New Drugs from Marine Organisms in Alzheimer’s Disease |
title_full | New Drugs from Marine Organisms in Alzheimer’s Disease |
title_fullStr | New Drugs from Marine Organisms in Alzheimer’s Disease |
title_full_unstemmed | New Drugs from Marine Organisms in Alzheimer’s Disease |
title_short | New Drugs from Marine Organisms in Alzheimer’s Disease |
title_sort | new drugs from marine organisms in alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728502/ https://www.ncbi.nlm.nih.gov/pubmed/26712769 http://dx.doi.org/10.3390/md14010005 |
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