Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.

Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on t...

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Detalles Bibliográficos
Autores principales: Chang, Yu-Chia, Kuo, Liang-Mou, Hwang, Tsong-Long, Yeh, Jessica, Wen, Zhi-Hong, Fang, Lee-Shing, Wu, Yang-Chang, Lin, Chan-Shing, Sheu, Jyh-Horng, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728509/
https://www.ncbi.nlm.nih.gov/pubmed/26751457
http://dx.doi.org/10.3390/md14010012
Descripción
Sumario:Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).

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