Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.

Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on t...

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Autores principales: Chang, Yu-Chia, Kuo, Liang-Mou, Hwang, Tsong-Long, Yeh, Jessica, Wen, Zhi-Hong, Fang, Lee-Shing, Wu, Yang-Chang, Lin, Chan-Shing, Sheu, Jyh-Horng, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728509/
https://www.ncbi.nlm.nih.gov/pubmed/26751457
http://dx.doi.org/10.3390/md14010012
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author Chang, Yu-Chia
Kuo, Liang-Mou
Hwang, Tsong-Long
Yeh, Jessica
Wen, Zhi-Hong
Fang, Lee-Shing
Wu, Yang-Chang
Lin, Chan-Shing
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_facet Chang, Yu-Chia
Kuo, Liang-Mou
Hwang, Tsong-Long
Yeh, Jessica
Wen, Zhi-Hong
Fang, Lee-Shing
Wu, Yang-Chang
Lin, Chan-Shing
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_sort Chang, Yu-Chia
collection PubMed
description Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).
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spelling pubmed-47285092016-02-08 Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp. Chang, Yu-Chia Kuo, Liang-Mou Hwang, Tsong-Long Yeh, Jessica Wen, Zhi-Hong Fang, Lee-Shing Wu, Yang-Chang Lin, Chan-Shing Sheu, Jyh-Horng Sung, Ping-Jyun Mar Drugs Article Three new 9,11-secosterols, pinnisterols A–C (1–3), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs). MDPI 2016-01-07 /pmc/articles/PMC4728509/ /pubmed/26751457 http://dx.doi.org/10.3390/md14010012 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Yu-Chia
Kuo, Liang-Mou
Hwang, Tsong-Long
Yeh, Jessica
Wen, Zhi-Hong
Fang, Lee-Shing
Wu, Yang-Chang
Lin, Chan-Shing
Sheu, Jyh-Horng
Sung, Ping-Jyun
Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
title Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
title_full Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
title_fullStr Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
title_full_unstemmed Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
title_short Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
title_sort pinnisterols a–c, new 9,11-secosterols from a gorgonian pinnigorgia sp.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728509/
https://www.ncbi.nlm.nih.gov/pubmed/26751457
http://dx.doi.org/10.3390/md14010012
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