PRMT5 Is Upregulated in HTLV-1-Mediated T-Cell Transformation and Selective Inhibition Alters Viral Gene Expression and Infected Cell Survival

Human T-cell leukemia virus type-1 (HTLV-1) is a tumorigenic retrovirus responsible for development of adult T-cell leukemia/lymphoma (ATLL). This disease manifests after a long clinical latency period of up to 2–3 decades. Two viral gene products, Tax and HBZ, have transforming properties and play...

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Detalles Bibliográficos
Autores principales: Panfil, Amanda R., Al-Saleem, Jacob, Howard, Cory M., Mates, Jessica M., Kwiek, Jesse J., Baiocchi, Robert A., Green, Patrick L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728567/
https://www.ncbi.nlm.nih.gov/pubmed/26729154
http://dx.doi.org/10.3390/v8010007

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