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Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction

Enterovirus genus includes multiple important human pathogens, such as poliovirus, coxsackievirus, enterovirus (EV) A71, EV-D68 and rhinovirus. Infection with EVs can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid p...

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Autores principales: Lei, Xiaobo, Xiao, Xia, Wang, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728582/
https://www.ncbi.nlm.nih.gov/pubmed/26784219
http://dx.doi.org/10.3390/v8010022
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author Lei, Xiaobo
Xiao, Xia
Wang, Jianwei
author_facet Lei, Xiaobo
Xiao, Xia
Wang, Jianwei
author_sort Lei, Xiaobo
collection PubMed
description Enterovirus genus includes multiple important human pathogens, such as poliovirus, coxsackievirus, enterovirus (EV) A71, EV-D68 and rhinovirus. Infection with EVs can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid paralysis, diarrhea, myocarditis and respiratory illness. EVs, which are positive-sense single-stranded RNA viruses, trigger activation of the host antiviral innate immune responses through pathogen recognition receptors such as retinoic acid-inducible gene (RIG-I)-likeand Toll-like receptors. In turn, EVs have developed sophisticated strategies to evade host antiviral responses. In this review, we discuss the interplay between the host innate immune responses and EV infection, with a primary focus on host immune detection and protection against EV infection and viral strategies to evade these antiviral immune responses.
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spelling pubmed-47285822016-02-08 Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction Lei, Xiaobo Xiao, Xia Wang, Jianwei Viruses Review Enterovirus genus includes multiple important human pathogens, such as poliovirus, coxsackievirus, enterovirus (EV) A71, EV-D68 and rhinovirus. Infection with EVs can cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acute flaccid paralysis, diarrhea, myocarditis and respiratory illness. EVs, which are positive-sense single-stranded RNA viruses, trigger activation of the host antiviral innate immune responses through pathogen recognition receptors such as retinoic acid-inducible gene (RIG-I)-likeand Toll-like receptors. In turn, EVs have developed sophisticated strategies to evade host antiviral responses. In this review, we discuss the interplay between the host innate immune responses and EV infection, with a primary focus on host immune detection and protection against EV infection and viral strategies to evade these antiviral immune responses. MDPI 2016-01-15 /pmc/articles/PMC4728582/ /pubmed/26784219 http://dx.doi.org/10.3390/v8010022 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lei, Xiaobo
Xiao, Xia
Wang, Jianwei
Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction
title Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction
title_full Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction
title_fullStr Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction
title_full_unstemmed Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction
title_short Innate Immunity Evasion by Enteroviruses: Insights into Virus-Host Interaction
title_sort innate immunity evasion by enteroviruses: insights into virus-host interaction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728582/
https://www.ncbi.nlm.nih.gov/pubmed/26784219
http://dx.doi.org/10.3390/v8010022
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