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Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events

BACKGROUND: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. OBJECTIVE: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated...

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Autores principales: Cho, Sung Woo, Kim, Byung Gyu, Kim, Byung Ok, Byun, Young Sup, Goh, Choong Won, Rhee, Kun Joo, Kwon, Hyuck Moon, Lee, Byoung Kwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia - SBC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728596/
https://www.ncbi.nlm.nih.gov/pubmed/26690693
http://dx.doi.org/10.5935/abc.20150146
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author Cho, Sung Woo
Kim, Byung Gyu
Kim, Byung Ok
Byun, Young Sup
Goh, Choong Won
Rhee, Kun Joo
Kwon, Hyuck Moon
Lee, Byoung Kwon
author_facet Cho, Sung Woo
Kim, Byung Gyu
Kim, Byung Ok
Byun, Young Sup
Goh, Choong Won
Rhee, Kun Joo
Kwon, Hyuck Moon
Lee, Byoung Kwon
author_sort Cho, Sung Woo
collection PubMed
description BACKGROUND: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. OBJECTIVE: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. METHODS: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. RESULTS: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. CONCLUSION: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients.
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spelling pubmed-47285962016-01-29 Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events Cho, Sung Woo Kim, Byung Gyu Kim, Byung Ok Byun, Young Sup Goh, Choong Won Rhee, Kun Joo Kwon, Hyuck Moon Lee, Byoung Kwon Arq Bras Cardiol Original Articles BACKGROUND: Hemorheological and glycemic parameters and high density lipoprotein (HDL) cholesterol are used as biomarkers of atherosclerosis and thrombosis. OBJECTIVE: To investigate the association and clinical relevance of erythrocyte sedimentation rate (ESR), fibrinogen, fasting glucose, glycated hemoglobin (HbA1c), and HDL cholesterol in the prediction of major adverse cardiovascular events (MACE) and coronary heart disease (CHD) in an outpatient population. METHODS: 708 stable patients who visited the outpatient department were enrolled and followed for a mean period of 28.5 months. Patients were divided into two groups, patients without MACE and patients with MACE, which included cardiac death, acute myocardial infarction, newly diagnosed CHD, and cerebral vascular accident. We compared hemorheological and glycemic parameters and lipid profiles between the groups. RESULTS: Patients with MACE had significantly higher ESR, fibrinogen, fasting glucose, and HbA1c, while lower HDL cholesterol compared with patients without MACE. High ESR and fibrinogen and low HDL cholesterol significantly increased the risk of MACE in multivariate regression analysis. In patients with MACE, high fibrinogen and HbA1c levels increased the risk of multivessel CHD. Furthermore, ESR and fibrinogen were significantly positively correlated with HbA1c and negatively correlated with HDL cholesterol, however not correlated with fasting glucose. CONCLUSION: Hemorheological abnormalities, poor glycemic control, and low HDL cholesterol are correlated with each other and could serve as simple and useful surrogate markers and predictors for MACE and CHD in outpatients. Sociedade Brasileira de Cardiologia - SBC 2016-01 /pmc/articles/PMC4728596/ /pubmed/26690693 http://dx.doi.org/10.5935/abc.20150146 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Cho, Sung Woo
Kim, Byung Gyu
Kim, Byung Ok
Byun, Young Sup
Goh, Choong Won
Rhee, Kun Joo
Kwon, Hyuck Moon
Lee, Byoung Kwon
Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events
title Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events
title_full Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events
title_fullStr Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events
title_full_unstemmed Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events
title_short Hemorheological and Glycemic Parameters and HDL Cholesterol for the Prediction of Cardiovascular Events
title_sort hemorheological and glycemic parameters and hdl cholesterol for the prediction of cardiovascular events
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728596/
https://www.ncbi.nlm.nih.gov/pubmed/26690693
http://dx.doi.org/10.5935/abc.20150146
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