Serum concentrations of clarithromycin and rifampicin in pulmonary Mycobacterium avium complex disease: long-term changes due to drug interactions and their association with clinical outcomes

BACKGROUND: Concomitant use of clarithromycin (CAM) and rifampicin (RFP) for the treatment of pulmonary Mycobacterium avium complex (MAC) disease affects the systemic concentrations of both drugs due to CYP3A4–related interactions. To date, however, there has been no report that investigates the lon...

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Detalles Bibliográficos
Autores principales: Shimomura, Hitoshi, Andachi, Sena, Aono, Takahiro, Kigure, Akira, Yamamoto, Yosuke, Miyajima, Atsushi, Hirota, Takashi, Imanaka, Keiko, Majima, Toru, Masuyama, Hidenori, Tatsumi, Koichiro, Aoyama, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728759/
https://www.ncbi.nlm.nih.gov/pubmed/26819743
http://dx.doi.org/10.1186/s40780-015-0029-0

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