Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease

Previous studies have reported very different rates of human rhinovirus (HRV) and respiratory syncytial virus (RSV) genome detection in nasal and sputum samples, but not in bronchoalveolar lavage (BAL) and bronchial biopsy samples. Our study aimed to investigate the presence of HRV and RSV in the lu...

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Autores principales: Giannakaki, Styliani, Politi, Lida, Antonogiannaki, Elvira Markella, Spanakis, Nick, Arsenis, Georgios, Filaditaki, Vasiliki, Zakynthinos, Spyridon, Karagiannidis, Napoleon, Tsakris, Athanassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728766/
https://www.ncbi.nlm.nih.gov/pubmed/26819185
http://dx.doi.org/10.1186/s12931-016-0323-x
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author Giannakaki, Styliani
Politi, Lida
Antonogiannaki, Elvira Markella
Spanakis, Nick
Arsenis, Georgios
Filaditaki, Vasiliki
Zakynthinos, Spyridon
Karagiannidis, Napoleon
Tsakris, Athanassios
author_facet Giannakaki, Styliani
Politi, Lida
Antonogiannaki, Elvira Markella
Spanakis, Nick
Arsenis, Georgios
Filaditaki, Vasiliki
Zakynthinos, Spyridon
Karagiannidis, Napoleon
Tsakris, Athanassios
author_sort Giannakaki, Styliani
collection PubMed
description Previous studies have reported very different rates of human rhinovirus (HRV) and respiratory syncytial virus (RSV) genome detection in nasal and sputum samples, but not in bronchoalveolar lavage (BAL) and bronchial biopsy samples. Our study aimed to investigate the presence of HRV and RSV in the lungs of 31 consecutive patients with stable COPD (11 GOLD stage I, 11 II, and 9 III) and 22 control subjects (12 current or past smokers, and 10 non-smokers), who underwent diagnostic (e.g., lung cancer) and/or therapeutic (e.g., hemoptysis) fibreoptic bronchoscopy in a university hospital in Athens, Greece. Viral RNA of HRV and RSV were not detected in any of the samples of COPD patients or control subjects after being processed with real-time PCR.
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spelling pubmed-47287662016-01-27 Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease Giannakaki, Styliani Politi, Lida Antonogiannaki, Elvira Markella Spanakis, Nick Arsenis, Georgios Filaditaki, Vasiliki Zakynthinos, Spyridon Karagiannidis, Napoleon Tsakris, Athanassios Respir Res Editorial Previous studies have reported very different rates of human rhinovirus (HRV) and respiratory syncytial virus (RSV) genome detection in nasal and sputum samples, but not in bronchoalveolar lavage (BAL) and bronchial biopsy samples. Our study aimed to investigate the presence of HRV and RSV in the lungs of 31 consecutive patients with stable COPD (11 GOLD stage I, 11 II, and 9 III) and 22 control subjects (12 current or past smokers, and 10 non-smokers), who underwent diagnostic (e.g., lung cancer) and/or therapeutic (e.g., hemoptysis) fibreoptic bronchoscopy in a university hospital in Athens, Greece. Viral RNA of HRV and RSV were not detected in any of the samples of COPD patients or control subjects after being processed with real-time PCR. BioMed Central 2016-01-27 2016 /pmc/articles/PMC4728766/ /pubmed/26819185 http://dx.doi.org/10.1186/s12931-016-0323-x Text en © Giannakaki et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Editorial
Giannakaki, Styliani
Politi, Lida
Antonogiannaki, Elvira Markella
Spanakis, Nick
Arsenis, Georgios
Filaditaki, Vasiliki
Zakynthinos, Spyridon
Karagiannidis, Napoleon
Tsakris, Athanassios
Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease
title Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease
title_full Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease
title_fullStr Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease
title_full_unstemmed Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease
title_short Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease
title_sort absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728766/
https://www.ncbi.nlm.nih.gov/pubmed/26819185
http://dx.doi.org/10.1186/s12931-016-0323-x
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