Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer

BACKGROUND: One of the hallmarks of cancer is the disruption of gene expression patterns. Many molecular lesions contribute to this phenotype, and the importance of aberrant DNA methylation profiles is increasingly recognized. Much of the research effort in this area has examined proximal promoter r...

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Detalles Bibliográficos
Autores principales: Heyn, Holger, Vidal, Enrique, Ferreira, Humberto J., Vizoso, Miguel, Sayols, Sergi, Gomez, Antonio, Moran, Sebastian, Boque-Sastre, Raquel, Guil, Sonia, Martinez-Cardus, Anna, Lin, Charles Y., Royo, Romina, Sanchez-Mut, Jose V., Martinez, Ramon, Gut, Marta, Torrents, David, Orozco, Modesto, Gut, Ivo, Young, Richard A., Esteller, Manel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728783/
https://www.ncbi.nlm.nih.gov/pubmed/26813288
http://dx.doi.org/10.1186/s13059-016-0879-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728783/
https://www.ncbi.nlm.nih.gov/pubmed/26813288
http://dx.doi.org/10.1186/s13059-016-0879-2

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