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Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients

BACKGROUND: This study aimed to evaluate the population pharmacokinetics of digoxin in Japanese patients and establish a dosage regimen based on the pharmacokinetic data. METHODS: We analyzed 287 serum digoxin samples from 192 individuals by using the nonlinear mixed effects model. We used simulatio...

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Detalles Bibliográficos
Autores principales:	Komatsu, Toshiaki, Morita, Mami, Miyaji, Futaba, Inomata, Takayuki, Ako, Junya, Atsuda, Koichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728823/ https://www.ncbi.nlm.nih.gov/pubmed/26819736 http://dx.doi.org/10.1186/s40780-015-0023-6

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