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Population pharmacokinetics and optimization of the dosing regimen of digoxin in adult patients
BACKGROUND: This study aimed to evaluate the population pharmacokinetics of digoxin in Japanese patients and establish a dosage regimen based on the pharmacokinetic data. METHODS: We analyzed 287 serum digoxin samples from 192 individuals by using the nonlinear mixed effects model. We used simulatio...
Autores principales: | Komatsu, Toshiaki, Morita, Mami, Miyaji, Futaba, Inomata, Takayuki, Ako, Junya, Atsuda, Koichiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728823/ https://www.ncbi.nlm.nih.gov/pubmed/26819736 http://dx.doi.org/10.1186/s40780-015-0023-6 |
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