H2AX phosphorylation and DNA damage kinase activity are dispensable for herpes simplex virus replication

BACKGROUND: Herpes simplex virus type 1 (HSV-1) can establish both lytic and latent infections in humans. The phosphorylation of histone H2AX, a common marker of DNA damage, during lytic infection by HSV-1 is well established. However, the role(s) of H2AX phosphorylation in lytic infection remain un...

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Detalles Bibliográficos
Autores principales: Botting, Carolyn, Lu, Xu, Triezenberg, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728825/
https://www.ncbi.nlm.nih.gov/pubmed/26817608
http://dx.doi.org/10.1186/s12985-016-0470-1

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