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Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India

PURPOSE: To investigate outcomes for different treatment modalities in congenital nasolacrimal duct obstruction (CNLDO) in an Indian population. DESIGN: Retrospective, interventional, case series. MATERIALS AND METHODS: In an institutional setting, case records of patients with CNLDO from January 20...

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Autores principales: Bhandari, Sahil, Sengupta, Sabyasachi, Yadalla, Dayakar, Rajagopalan, Jayagayathri, Velis, Girish Bharat, Talele, Deepti, Kushwaha, Sameer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728972/
https://www.ncbi.nlm.nih.gov/pubmed/26654998
http://dx.doi.org/10.4103/0301-4738.171503
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author Bhandari, Sahil
Sengupta, Sabyasachi
Yadalla, Dayakar
Rajagopalan, Jayagayathri
Velis, Girish Bharat
Talele, Deepti
Kushwaha, Sameer
author_facet Bhandari, Sahil
Sengupta, Sabyasachi
Yadalla, Dayakar
Rajagopalan, Jayagayathri
Velis, Girish Bharat
Talele, Deepti
Kushwaha, Sameer
author_sort Bhandari, Sahil
collection PubMed
description PURPOSE: To investigate outcomes for different treatment modalities in congenital nasolacrimal duct obstruction (CNLDO) in an Indian population. DESIGN: Retrospective, interventional, case series. MATERIALS AND METHODS: In an institutional setting, case records of patients with CNLDO from January 2008 to 2012, were reviewed, and data on patient demographics, clinical presentation, and treatment details (sac massage, probing, and/or dacryocystorhinostomy) were recorded. Success of treatment was defined as complete resolution of symptoms and negative regurgitation on pressure over lacrimal sac (ROPLAS) area. RESULTS: Two hundred and ninety-eight eyes of 240 patients with a mean age of 22.2 ± 26.14 months (median = 12 months, interquartile range = 17) were analyzed. Sac massage (n = 226) was successful in 67 eyes (30%). Multivariable logistic regression analyses showed that children with mucoid ROPLAS were almost 6 times more likely (odds ratio [OR] = 5.55 vs. clear ROPLAS, 95% confidence interval [CI] = 2.35–13.09, P < 0.001) to experience failure of sac massage. Overall probing (n = 193) was successful for 143 (74%) eyes. Multivariable logistic regression showed that older children were 25% more likely to experience probing failure (OR = 1.25 for every 6 months increment in age, 95%, CI = 1.09–1.42, P = 0.001). CONCLUSION: Sac massage is successful in only a third of our patients and those with mucoid ROPLAS are more likely to experience failure. Probing is successful in three-quarter of our subjects, and its success declines with a progressive increase in age. Lower socioeconomic status, poor general health, and recurrent respiratory infections are unique to our population and may influence outcomes.
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spelling pubmed-47289722016-02-10 Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India Bhandari, Sahil Sengupta, Sabyasachi Yadalla, Dayakar Rajagopalan, Jayagayathri Velis, Girish Bharat Talele, Deepti Kushwaha, Sameer Indian J Ophthalmol Original Article PURPOSE: To investigate outcomes for different treatment modalities in congenital nasolacrimal duct obstruction (CNLDO) in an Indian population. DESIGN: Retrospective, interventional, case series. MATERIALS AND METHODS: In an institutional setting, case records of patients with CNLDO from January 2008 to 2012, were reviewed, and data on patient demographics, clinical presentation, and treatment details (sac massage, probing, and/or dacryocystorhinostomy) were recorded. Success of treatment was defined as complete resolution of symptoms and negative regurgitation on pressure over lacrimal sac (ROPLAS) area. RESULTS: Two hundred and ninety-eight eyes of 240 patients with a mean age of 22.2 ± 26.14 months (median = 12 months, interquartile range = 17) were analyzed. Sac massage (n = 226) was successful in 67 eyes (30%). Multivariable logistic regression analyses showed that children with mucoid ROPLAS were almost 6 times more likely (odds ratio [OR] = 5.55 vs. clear ROPLAS, 95% confidence interval [CI] = 2.35–13.09, P < 0.001) to experience failure of sac massage. Overall probing (n = 193) was successful for 143 (74%) eyes. Multivariable logistic regression showed that older children were 25% more likely to experience probing failure (OR = 1.25 for every 6 months increment in age, 95%, CI = 1.09–1.42, P = 0.001). CONCLUSION: Sac massage is successful in only a third of our patients and those with mucoid ROPLAS are more likely to experience failure. Probing is successful in three-quarter of our subjects, and its success declines with a progressive increase in age. Lower socioeconomic status, poor general health, and recurrent respiratory infections are unique to our population and may influence outcomes. Medknow Publications & Media Pvt Ltd 2015-10 /pmc/articles/PMC4728972/ /pubmed/26654998 http://dx.doi.org/10.4103/0301-4738.171503 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Bhandari, Sahil
Sengupta, Sabyasachi
Yadalla, Dayakar
Rajagopalan, Jayagayathri
Velis, Girish Bharat
Talele, Deepti
Kushwaha, Sameer
Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India
title Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India
title_full Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India
title_fullStr Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India
title_full_unstemmed Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India
title_short Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India
title_sort factors affecting treatment outcome in congenital nasolacrimal duct obstruction: a retrospective analysis from south india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728972/
https://www.ncbi.nlm.nih.gov/pubmed/26654998
http://dx.doi.org/10.4103/0301-4738.171503
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