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Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India
PURPOSE: To investigate outcomes for different treatment modalities in congenital nasolacrimal duct obstruction (CNLDO) in an Indian population. DESIGN: Retrospective, interventional, case series. MATERIALS AND METHODS: In an institutional setting, case records of patients with CNLDO from January 20...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728972/ https://www.ncbi.nlm.nih.gov/pubmed/26654998 http://dx.doi.org/10.4103/0301-4738.171503 |
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author | Bhandari, Sahil Sengupta, Sabyasachi Yadalla, Dayakar Rajagopalan, Jayagayathri Velis, Girish Bharat Talele, Deepti Kushwaha, Sameer |
author_facet | Bhandari, Sahil Sengupta, Sabyasachi Yadalla, Dayakar Rajagopalan, Jayagayathri Velis, Girish Bharat Talele, Deepti Kushwaha, Sameer |
author_sort | Bhandari, Sahil |
collection | PubMed |
description | PURPOSE: To investigate outcomes for different treatment modalities in congenital nasolacrimal duct obstruction (CNLDO) in an Indian population. DESIGN: Retrospective, interventional, case series. MATERIALS AND METHODS: In an institutional setting, case records of patients with CNLDO from January 2008 to 2012, were reviewed, and data on patient demographics, clinical presentation, and treatment details (sac massage, probing, and/or dacryocystorhinostomy) were recorded. Success of treatment was defined as complete resolution of symptoms and negative regurgitation on pressure over lacrimal sac (ROPLAS) area. RESULTS: Two hundred and ninety-eight eyes of 240 patients with a mean age of 22.2 ± 26.14 months (median = 12 months, interquartile range = 17) were analyzed. Sac massage (n = 226) was successful in 67 eyes (30%). Multivariable logistic regression analyses showed that children with mucoid ROPLAS were almost 6 times more likely (odds ratio [OR] = 5.55 vs. clear ROPLAS, 95% confidence interval [CI] = 2.35–13.09, P < 0.001) to experience failure of sac massage. Overall probing (n = 193) was successful for 143 (74%) eyes. Multivariable logistic regression showed that older children were 25% more likely to experience probing failure (OR = 1.25 for every 6 months increment in age, 95%, CI = 1.09–1.42, P = 0.001). CONCLUSION: Sac massage is successful in only a third of our patients and those with mucoid ROPLAS are more likely to experience failure. Probing is successful in three-quarter of our subjects, and its success declines with a progressive increase in age. Lower socioeconomic status, poor general health, and recurrent respiratory infections are unique to our population and may influence outcomes. |
format | Online Article Text |
id | pubmed-4728972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47289722016-02-10 Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India Bhandari, Sahil Sengupta, Sabyasachi Yadalla, Dayakar Rajagopalan, Jayagayathri Velis, Girish Bharat Talele, Deepti Kushwaha, Sameer Indian J Ophthalmol Original Article PURPOSE: To investigate outcomes for different treatment modalities in congenital nasolacrimal duct obstruction (CNLDO) in an Indian population. DESIGN: Retrospective, interventional, case series. MATERIALS AND METHODS: In an institutional setting, case records of patients with CNLDO from January 2008 to 2012, were reviewed, and data on patient demographics, clinical presentation, and treatment details (sac massage, probing, and/or dacryocystorhinostomy) were recorded. Success of treatment was defined as complete resolution of symptoms and negative regurgitation on pressure over lacrimal sac (ROPLAS) area. RESULTS: Two hundred and ninety-eight eyes of 240 patients with a mean age of 22.2 ± 26.14 months (median = 12 months, interquartile range = 17) were analyzed. Sac massage (n = 226) was successful in 67 eyes (30%). Multivariable logistic regression analyses showed that children with mucoid ROPLAS were almost 6 times more likely (odds ratio [OR] = 5.55 vs. clear ROPLAS, 95% confidence interval [CI] = 2.35–13.09, P < 0.001) to experience failure of sac massage. Overall probing (n = 193) was successful for 143 (74%) eyes. Multivariable logistic regression showed that older children were 25% more likely to experience probing failure (OR = 1.25 for every 6 months increment in age, 95%, CI = 1.09–1.42, P = 0.001). CONCLUSION: Sac massage is successful in only a third of our patients and those with mucoid ROPLAS are more likely to experience failure. Probing is successful in three-quarter of our subjects, and its success declines with a progressive increase in age. Lower socioeconomic status, poor general health, and recurrent respiratory infections are unique to our population and may influence outcomes. Medknow Publications & Media Pvt Ltd 2015-10 /pmc/articles/PMC4728972/ /pubmed/26654998 http://dx.doi.org/10.4103/0301-4738.171503 Text en Copyright: © Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Bhandari, Sahil Sengupta, Sabyasachi Yadalla, Dayakar Rajagopalan, Jayagayathri Velis, Girish Bharat Talele, Deepti Kushwaha, Sameer Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India |
title | Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India |
title_full | Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India |
title_fullStr | Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India |
title_full_unstemmed | Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India |
title_short | Factors affecting treatment outcome in congenital nasolacrimal duct obstruction: A retrospective analysis from South India |
title_sort | factors affecting treatment outcome in congenital nasolacrimal duct obstruction: a retrospective analysis from south india |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728972/ https://www.ncbi.nlm.nih.gov/pubmed/26654998 http://dx.doi.org/10.4103/0301-4738.171503 |
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