Oral hyaluronan relieves knee pain: a review

Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief...

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Detalles Bibliográficos
Autores principales: Oe, Mariko, Tashiro, Toshiyuki, Yoshida, Hideto, Nishiyama, Hiroshi, Masuda, Yasunobu, Maruyama, Koh, Koikeda, Takashi, Maruya, Reiko, Fukui, Naoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729158/
https://www.ncbi.nlm.nih.gov/pubmed/26818459
http://dx.doi.org/10.1186/s12937-016-0128-2
Descripción
Sumario:Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA.

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