Oral hyaluronan relieves knee pain: a review

Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief...

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Autores principales: Oe, Mariko, Tashiro, Toshiyuki, Yoshida, Hideto, Nishiyama, Hiroshi, Masuda, Yasunobu, Maruyama, Koh, Koikeda, Takashi, Maruya, Reiko, Fukui, Naoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729158/
https://www.ncbi.nlm.nih.gov/pubmed/26818459
http://dx.doi.org/10.1186/s12937-016-0128-2
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author Oe, Mariko
Tashiro, Toshiyuki
Yoshida, Hideto
Nishiyama, Hiroshi
Masuda, Yasunobu
Maruyama, Koh
Koikeda, Takashi
Maruya, Reiko
Fukui, Naoshi
author_facet Oe, Mariko
Tashiro, Toshiyuki
Yoshida, Hideto
Nishiyama, Hiroshi
Masuda, Yasunobu
Maruyama, Koh
Koikeda, Takashi
Maruya, Reiko
Fukui, Naoshi
author_sort Oe, Mariko
collection PubMed
description Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA.
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spelling pubmed-47291582016-01-28 Oral hyaluronan relieves knee pain: a review Oe, Mariko Tashiro, Toshiyuki Yoshida, Hideto Nishiyama, Hiroshi Masuda, Yasunobu Maruyama, Koh Koikeda, Takashi Maruya, Reiko Fukui, Naoshi Nutr J Review Hyaluronan (HA) is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between 2008 and 2015 have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain, relief of synovial effusion or inflammation, and improvement of muscular knee strength. The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA. BioMed Central 2016-01-27 /pmc/articles/PMC4729158/ /pubmed/26818459 http://dx.doi.org/10.1186/s12937-016-0128-2 Text en © Oe et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Oe, Mariko
Tashiro, Toshiyuki
Yoshida, Hideto
Nishiyama, Hiroshi
Masuda, Yasunobu
Maruyama, Koh
Koikeda, Takashi
Maruya, Reiko
Fukui, Naoshi
Oral hyaluronan relieves knee pain: a review
title Oral hyaluronan relieves knee pain: a review
title_full Oral hyaluronan relieves knee pain: a review
title_fullStr Oral hyaluronan relieves knee pain: a review
title_full_unstemmed Oral hyaluronan relieves knee pain: a review
title_short Oral hyaluronan relieves knee pain: a review
title_sort oral hyaluronan relieves knee pain: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729158/
https://www.ncbi.nlm.nih.gov/pubmed/26818459
http://dx.doi.org/10.1186/s12937-016-0128-2
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