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Mixed-strain housing for female C57BL/6, DBA/2, and BALB/c mice: validating a split-plot design that promotes refinement and reduction
BACKGROUND: Inefficient experimental designs are common in animal-based biomedical research, wasting resources and potentially leading to unreplicable results. Here we illustrate the intrinsic statistical power of split-plot designs, wherein three or more sub-units (e.g. individual subjects) differi...
Autores principales: | Walker, Michael, Fureix, Carole, Palme, Rupert, Newman, Jonathan A., Ahloy Dallaire, Jamie, Mason, Georgia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729181/ https://www.ncbi.nlm.nih.gov/pubmed/26817696 http://dx.doi.org/10.1186/s12874-016-0113-7 |
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