Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione

New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of...

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Autores principales: Kononevich, Yuriy M., Bobkova, Ludmila S., Smolski, Alexander S., Demchenko, Anatoly M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729228/
https://www.ncbi.nlm.nih.gov/pubmed/26839800
http://dx.doi.org/10.3797/scipharm.1406-09
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author Kononevich, Yuriy M.
Bobkova, Ludmila S.
Smolski, Alexander S.
Demchenko, Anatoly M.
author_facet Kononevich, Yuriy M.
Bobkova, Ludmila S.
Smolski, Alexander S.
Demchenko, Anatoly M.
author_sort Kononevich, Yuriy M.
collection PubMed
description New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of Fe(2+)-dependent oxidation of adrenaline in vitro. It was found that the antiradical activity of 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione significantly depends on the structure of the substituent which is part of the thioether fragment of the base molecule.
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spelling pubmed-47292282016-02-02 Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione Kononevich, Yuriy M. Bobkova, Ludmila S. Smolski, Alexander S. Demchenko, Anatoly M. Sci Pharm Research Article New 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione have been synthesized by the reaction of 3-cyclohexyl-7-thio-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione with alkylhalogenides. The synthesized compounds were tested for antioxidant activity on the model of Fe(2+)-dependent oxidation of adrenaline in vitro. It was found that the antiradical activity of 7-thio derivatives of 6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione significantly depends on the structure of the substituent which is part of the thioether fragment of the base molecule. The Austrian Journal of Pharmaceutical Sciences 2015 2014-10-29 /pmc/articles/PMC4729228/ /pubmed/26839800 http://dx.doi.org/10.3797/scipharm.1406-09 Text en Copyright: © Kononevich et al. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kononevich, Yuriy M.
Bobkova, Ludmila S.
Smolski, Alexander S.
Demchenko, Anatoly M.
Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione
title Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione
title_full Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione
title_fullStr Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione
title_full_unstemmed Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione
title_short Synthesis and Antioxidant Activity of 7-Thio Derivatives of 6,7-Dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione
title_sort synthesis and antioxidant activity of 7-thio derivatives of 6,7-dihydro-1h-cyclopenta[d]pyrimidine-2,4(3h,5h)-dione
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729228/
https://www.ncbi.nlm.nih.gov/pubmed/26839800
http://dx.doi.org/10.3797/scipharm.1406-09
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