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Development and Testing of a Magnetically Actuated Capsule Endoscopy for Obesity Treatment
Intra-gastric balloons (IGB) have become an efficient and less invasive method for obesity treatment. The use of traditional IGBs require complex insertion tools and flexible endoscopes to place and remove the balloon inside the patient’s stomach, which may cause discomfort and complications to the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729466/ https://www.ncbi.nlm.nih.gov/pubmed/26815309 http://dx.doi.org/10.1371/journal.pone.0148035 |
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author | Do, Thanh Nho Seah, Tian En Timothy Yu, Ho Khek Phee, Soo Jay |
author_facet | Do, Thanh Nho Seah, Tian En Timothy Yu, Ho Khek Phee, Soo Jay |
author_sort | Do, Thanh Nho |
collection | PubMed |
description | Intra-gastric balloons (IGB) have become an efficient and less invasive method for obesity treatment. The use of traditional IGBs require complex insertion tools and flexible endoscopes to place and remove the balloon inside the patient’s stomach, which may cause discomfort and complications to the patient. This paper introduces a new ingestible weight-loss capsule with a magnetically remote-controlled inflatable and deflatable balloon. To inflate the balloon, biocompatible effervescent chemicals are used. As the source of the actuation is provided via external magnetic fields, the magnetic capsule size can be significantly reduced compared to current weight-loss capsules in the literature. In addition, there are no limitations on the power supply. To lose weight, the obese subject needs only to swallow the magnetic capsule with a glass of water. Once the magnetic capsule has reached the patient’s stomach, the balloon will be wirelessly inflated to occupy gastric space and give the feeling of satiety. The balloon can be wirelessly deflated at any time to allow the magnetic capsule to travel down the intestine and exit the body via normal peristalsis. The optimal ratio between the acid and base to provide the desired gas volume is experimentally evaluated and presented. A prototype capsule (9.6mm x 27mm) is developed and experimentally validated in ex-vivo experiments. The unique ease of delivery and expulsion of the proposed magnetic capsule is slated to make this development a good treatment option for people seeking to lose excess weight. |
format | Online Article Text |
id | pubmed-4729466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47294662016-02-04 Development and Testing of a Magnetically Actuated Capsule Endoscopy for Obesity Treatment Do, Thanh Nho Seah, Tian En Timothy Yu, Ho Khek Phee, Soo Jay PLoS One Research Article Intra-gastric balloons (IGB) have become an efficient and less invasive method for obesity treatment. The use of traditional IGBs require complex insertion tools and flexible endoscopes to place and remove the balloon inside the patient’s stomach, which may cause discomfort and complications to the patient. This paper introduces a new ingestible weight-loss capsule with a magnetically remote-controlled inflatable and deflatable balloon. To inflate the balloon, biocompatible effervescent chemicals are used. As the source of the actuation is provided via external magnetic fields, the magnetic capsule size can be significantly reduced compared to current weight-loss capsules in the literature. In addition, there are no limitations on the power supply. To lose weight, the obese subject needs only to swallow the magnetic capsule with a glass of water. Once the magnetic capsule has reached the patient’s stomach, the balloon will be wirelessly inflated to occupy gastric space and give the feeling of satiety. The balloon can be wirelessly deflated at any time to allow the magnetic capsule to travel down the intestine and exit the body via normal peristalsis. The optimal ratio between the acid and base to provide the desired gas volume is experimentally evaluated and presented. A prototype capsule (9.6mm x 27mm) is developed and experimentally validated in ex-vivo experiments. The unique ease of delivery and expulsion of the proposed magnetic capsule is slated to make this development a good treatment option for people seeking to lose excess weight. Public Library of Science 2016-01-27 /pmc/articles/PMC4729466/ /pubmed/26815309 http://dx.doi.org/10.1371/journal.pone.0148035 Text en © 2016 Do et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Do, Thanh Nho Seah, Tian En Timothy Yu, Ho Khek Phee, Soo Jay Development and Testing of a Magnetically Actuated Capsule Endoscopy for Obesity Treatment |
title | Development and Testing of a Magnetically Actuated Capsule Endoscopy for Obesity Treatment |
title_full | Development and Testing of a Magnetically Actuated Capsule Endoscopy for Obesity Treatment |
title_fullStr | Development and Testing of a Magnetically Actuated Capsule Endoscopy for Obesity Treatment |
title_full_unstemmed | Development and Testing of a Magnetically Actuated Capsule Endoscopy for Obesity Treatment |
title_short | Development and Testing of a Magnetically Actuated Capsule Endoscopy for Obesity Treatment |
title_sort | development and testing of a magnetically actuated capsule endoscopy for obesity treatment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729466/ https://www.ncbi.nlm.nih.gov/pubmed/26815309 http://dx.doi.org/10.1371/journal.pone.0148035 |
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