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The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition

BACKGROUND: The entry of HIV into its host cell is an interesting target for chemotherapeutic intervention in the life-cycle of the virus. During entry, reduction of disulfide bridges in the viral envelope glycoprotein gp120 by cellular oxidoreductases is crucial. The cellular thioredoxin reductase-...

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Detalles Bibliográficos
Autores principales:	Reiser, Kathrin, Mathys, Leen, Curbo, Sophie, Pannecouque, Christophe, Noppen, Sam, Liekens, Sandra, Engman, Lars, Lundberg, Mathias, Balzarini, Jan, Karlsson, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729491/ https://www.ncbi.nlm.nih.gov/pubmed/26816344 http://dx.doi.org/10.1371/journal.pone.0147773

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