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Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis

BACKGROUND: Several host genetic factors are thought to affect susceptibility to Helicobacter pylori infection-related diseases, including tumor necrosis factor (TNF)-α. Previous studies have evaluated the association between TNFA gene polymorphisms and H. pylori infection, but the results were inco...

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Autores principales: Sun, Xudong, Xu, Yuanyuan, Wang, Li, Zhang, Fuhua, Zhang, Jinhua, Fu, Ximei, Jing, Tao, Han, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729674/
https://www.ncbi.nlm.nih.gov/pubmed/26815578
http://dx.doi.org/10.1371/journal.pone.0147410
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author Sun, Xudong
Xu, Yuanyuan
Wang, Li
Zhang, Fuhua
Zhang, Jinhua
Fu, Ximei
Jing, Tao
Han, Jian
author_facet Sun, Xudong
Xu, Yuanyuan
Wang, Li
Zhang, Fuhua
Zhang, Jinhua
Fu, Ximei
Jing, Tao
Han, Jian
author_sort Sun, Xudong
collection PubMed
description BACKGROUND: Several host genetic factors are thought to affect susceptibility to Helicobacter pylori infection-related diseases, including tumor necrosis factor (TNF)-α. Previous studies have evaluated the association between TNFA gene polymorphisms and H. pylori infection, but the results were inconclusive. We conducted this meta-analysis to clarify the association between TNFA polymorphisms and H. pylori infection. METHODS: Published literature within PubMed, Embase, and the Cochrane Library were used in our meta-analysis. Data were analyzed with the Stata13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (CI). RESULTS: A total of 24 studies were included in our study. The TNFA -308G>A polymorphism was associated with decreasing H. pylori infection (AA vs. AG+GG, OR = 0.64, 95% CI = 0.43–0.97; AA vs. GG, OR = 0.64, 95% CI = 0.43–0.97). A significantly decreased risk was also found for -1031T>C polymorphism (CC vs. CT+TT, OR = 0.61, 95% CI = 0.44–0.84). -863C>A polymorphism was associated with increasing risk of H. pylori infection (AA+AC vs. CC, OR = 1.47, 95% CI = 1.16–1.86; A allele vs. C allele, OR = 1.40, 95% CI = 1.14–1.72). There was no significant association between -857C>T polymorphism and H. pylori infection. When stratified analysis was conducted on H. pylori infection detection methods, -857C>T and -863C>A polymorphisms were associated with H. pylori infection for the non-ELISA subgroup. When stratified for ethnicity or study design, -863C>A significantly increased the risk and -1031T>C decreased the risk for the Asian subgroup and hospital-based subgroup. CONCLUSION: Results of our meta-analysis demonstrate that TNFA -308G>A and -1031 T>C polymorphisms may be protective factors against H. pylori infection, and -863C>A may be a risk factor, especially in Asian populations. Further studies with larger sample sizes are required to validate these results.
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spelling pubmed-47296742016-02-04 Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis Sun, Xudong Xu, Yuanyuan Wang, Li Zhang, Fuhua Zhang, Jinhua Fu, Ximei Jing, Tao Han, Jian PLoS One Research Article BACKGROUND: Several host genetic factors are thought to affect susceptibility to Helicobacter pylori infection-related diseases, including tumor necrosis factor (TNF)-α. Previous studies have evaluated the association between TNFA gene polymorphisms and H. pylori infection, but the results were inconclusive. We conducted this meta-analysis to clarify the association between TNFA polymorphisms and H. pylori infection. METHODS: Published literature within PubMed, Embase, and the Cochrane Library were used in our meta-analysis. Data were analyzed with the Stata13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (CI). RESULTS: A total of 24 studies were included in our study. The TNFA -308G>A polymorphism was associated with decreasing H. pylori infection (AA vs. AG+GG, OR = 0.64, 95% CI = 0.43–0.97; AA vs. GG, OR = 0.64, 95% CI = 0.43–0.97). A significantly decreased risk was also found for -1031T>C polymorphism (CC vs. CT+TT, OR = 0.61, 95% CI = 0.44–0.84). -863C>A polymorphism was associated with increasing risk of H. pylori infection (AA+AC vs. CC, OR = 1.47, 95% CI = 1.16–1.86; A allele vs. C allele, OR = 1.40, 95% CI = 1.14–1.72). There was no significant association between -857C>T polymorphism and H. pylori infection. When stratified analysis was conducted on H. pylori infection detection methods, -857C>T and -863C>A polymorphisms were associated with H. pylori infection for the non-ELISA subgroup. When stratified for ethnicity or study design, -863C>A significantly increased the risk and -1031T>C decreased the risk for the Asian subgroup and hospital-based subgroup. CONCLUSION: Results of our meta-analysis demonstrate that TNFA -308G>A and -1031 T>C polymorphisms may be protective factors against H. pylori infection, and -863C>A may be a risk factor, especially in Asian populations. Further studies with larger sample sizes are required to validate these results. Public Library of Science 2016-01-27 /pmc/articles/PMC4729674/ /pubmed/26815578 http://dx.doi.org/10.1371/journal.pone.0147410 Text en © 2016 Sun et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sun, Xudong
Xu, Yuanyuan
Wang, Li
Zhang, Fuhua
Zhang, Jinhua
Fu, Ximei
Jing, Tao
Han, Jian
Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis
title Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis
title_full Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis
title_fullStr Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis
title_full_unstemmed Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis
title_short Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis
title_sort association between tnfa gene polymorphisms and helicobacter pylori infection: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729674/
https://www.ncbi.nlm.nih.gov/pubmed/26815578
http://dx.doi.org/10.1371/journal.pone.0147410
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