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Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis
BACKGROUND: Several host genetic factors are thought to affect susceptibility to Helicobacter pylori infection-related diseases, including tumor necrosis factor (TNF)-α. Previous studies have evaluated the association between TNFA gene polymorphisms and H. pylori infection, but the results were inco...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729674/ https://www.ncbi.nlm.nih.gov/pubmed/26815578 http://dx.doi.org/10.1371/journal.pone.0147410 |
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author | Sun, Xudong Xu, Yuanyuan Wang, Li Zhang, Fuhua Zhang, Jinhua Fu, Ximei Jing, Tao Han, Jian |
author_facet | Sun, Xudong Xu, Yuanyuan Wang, Li Zhang, Fuhua Zhang, Jinhua Fu, Ximei Jing, Tao Han, Jian |
author_sort | Sun, Xudong |
collection | PubMed |
description | BACKGROUND: Several host genetic factors are thought to affect susceptibility to Helicobacter pylori infection-related diseases, including tumor necrosis factor (TNF)-α. Previous studies have evaluated the association between TNFA gene polymorphisms and H. pylori infection, but the results were inconclusive. We conducted this meta-analysis to clarify the association between TNFA polymorphisms and H. pylori infection. METHODS: Published literature within PubMed, Embase, and the Cochrane Library were used in our meta-analysis. Data were analyzed with the Stata13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (CI). RESULTS: A total of 24 studies were included in our study. The TNFA -308G>A polymorphism was associated with decreasing H. pylori infection (AA vs. AG+GG, OR = 0.64, 95% CI = 0.43–0.97; AA vs. GG, OR = 0.64, 95% CI = 0.43–0.97). A significantly decreased risk was also found for -1031T>C polymorphism (CC vs. CT+TT, OR = 0.61, 95% CI = 0.44–0.84). -863C>A polymorphism was associated with increasing risk of H. pylori infection (AA+AC vs. CC, OR = 1.47, 95% CI = 1.16–1.86; A allele vs. C allele, OR = 1.40, 95% CI = 1.14–1.72). There was no significant association between -857C>T polymorphism and H. pylori infection. When stratified analysis was conducted on H. pylori infection detection methods, -857C>T and -863C>A polymorphisms were associated with H. pylori infection for the non-ELISA subgroup. When stratified for ethnicity or study design, -863C>A significantly increased the risk and -1031T>C decreased the risk for the Asian subgroup and hospital-based subgroup. CONCLUSION: Results of our meta-analysis demonstrate that TNFA -308G>A and -1031 T>C polymorphisms may be protective factors against H. pylori infection, and -863C>A may be a risk factor, especially in Asian populations. Further studies with larger sample sizes are required to validate these results. |
format | Online Article Text |
id | pubmed-4729674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47296742016-02-04 Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis Sun, Xudong Xu, Yuanyuan Wang, Li Zhang, Fuhua Zhang, Jinhua Fu, Ximei Jing, Tao Han, Jian PLoS One Research Article BACKGROUND: Several host genetic factors are thought to affect susceptibility to Helicobacter pylori infection-related diseases, including tumor necrosis factor (TNF)-α. Previous studies have evaluated the association between TNFA gene polymorphisms and H. pylori infection, but the results were inconclusive. We conducted this meta-analysis to clarify the association between TNFA polymorphisms and H. pylori infection. METHODS: Published literature within PubMed, Embase, and the Cochrane Library were used in our meta-analysis. Data were analyzed with the Stata13.1 software package using pooled odds ratios (ORs) with 95% confidence intervals (CI). RESULTS: A total of 24 studies were included in our study. The TNFA -308G>A polymorphism was associated with decreasing H. pylori infection (AA vs. AG+GG, OR = 0.64, 95% CI = 0.43–0.97; AA vs. GG, OR = 0.64, 95% CI = 0.43–0.97). A significantly decreased risk was also found for -1031T>C polymorphism (CC vs. CT+TT, OR = 0.61, 95% CI = 0.44–0.84). -863C>A polymorphism was associated with increasing risk of H. pylori infection (AA+AC vs. CC, OR = 1.47, 95% CI = 1.16–1.86; A allele vs. C allele, OR = 1.40, 95% CI = 1.14–1.72). There was no significant association between -857C>T polymorphism and H. pylori infection. When stratified analysis was conducted on H. pylori infection detection methods, -857C>T and -863C>A polymorphisms were associated with H. pylori infection for the non-ELISA subgroup. When stratified for ethnicity or study design, -863C>A significantly increased the risk and -1031T>C decreased the risk for the Asian subgroup and hospital-based subgroup. CONCLUSION: Results of our meta-analysis demonstrate that TNFA -308G>A and -1031 T>C polymorphisms may be protective factors against H. pylori infection, and -863C>A may be a risk factor, especially in Asian populations. Further studies with larger sample sizes are required to validate these results. Public Library of Science 2016-01-27 /pmc/articles/PMC4729674/ /pubmed/26815578 http://dx.doi.org/10.1371/journal.pone.0147410 Text en © 2016 Sun et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sun, Xudong Xu, Yuanyuan Wang, Li Zhang, Fuhua Zhang, Jinhua Fu, Ximei Jing, Tao Han, Jian Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis |
title | Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis |
title_full | Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis |
title_fullStr | Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis |
title_full_unstemmed | Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis |
title_short | Association between TNFA Gene Polymorphisms and Helicobacter pylori Infection: A Meta-Analysis |
title_sort | association between tnfa gene polymorphisms and helicobacter pylori infection: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729674/ https://www.ncbi.nlm.nih.gov/pubmed/26815578 http://dx.doi.org/10.1371/journal.pone.0147410 |
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