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Misaligned feeding impairs memories
Robust sleep/wake rhythms are important for health and cognitive function. Unfortunately, many people are living in an environment where their circadian system is challenged by inappropriate meal- or work-times. Here we scheduled food access to the sleep time and examined the impact on learning and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729691/ https://www.ncbi.nlm.nih.gov/pubmed/26652002 http://dx.doi.org/10.7554/eLife.09460 |
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author | Loh, Dawn H Jami, Shekib A Flores, Richard E Truong, Danny Ghiani, Cristina A O’Dell, Thomas J Colwell, Christopher S |
author_facet | Loh, Dawn H Jami, Shekib A Flores, Richard E Truong, Danny Ghiani, Cristina A O’Dell, Thomas J Colwell, Christopher S |
author_sort | Loh, Dawn H |
collection | PubMed |
description | Robust sleep/wake rhythms are important for health and cognitive function. Unfortunately, many people are living in an environment where their circadian system is challenged by inappropriate meal- or work-times. Here we scheduled food access to the sleep time and examined the impact on learning and memory in mice. Under these conditions, we demonstrate that the molecular clock in the master pacemaker, the suprachiasmatic nucleus (SCN), is unaltered while the molecular clock in the hippocampus is synchronized by the timing of food availability. This chronic circadian misalignment causes reduced hippocampal long term potentiation and total CREB expression. Importantly this mis-timed feeding resulted in dramatic deficits in hippocampal-dependent learning and memory. Our findings suggest that the timing of meals have far-reaching effects on hippocampal physiology and learned behaviour. DOI: http://dx.doi.org/10.7554/eLife.09460.001 |
format | Online Article Text |
id | pubmed-4729691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47296912016-01-28 Misaligned feeding impairs memories Loh, Dawn H Jami, Shekib A Flores, Richard E Truong, Danny Ghiani, Cristina A O’Dell, Thomas J Colwell, Christopher S eLife Neuroscience Robust sleep/wake rhythms are important for health and cognitive function. Unfortunately, many people are living in an environment where their circadian system is challenged by inappropriate meal- or work-times. Here we scheduled food access to the sleep time and examined the impact on learning and memory in mice. Under these conditions, we demonstrate that the molecular clock in the master pacemaker, the suprachiasmatic nucleus (SCN), is unaltered while the molecular clock in the hippocampus is synchronized by the timing of food availability. This chronic circadian misalignment causes reduced hippocampal long term potentiation and total CREB expression. Importantly this mis-timed feeding resulted in dramatic deficits in hippocampal-dependent learning and memory. Our findings suggest that the timing of meals have far-reaching effects on hippocampal physiology and learned behaviour. DOI: http://dx.doi.org/10.7554/eLife.09460.001 eLife Sciences Publications, Ltd 2015-12-10 /pmc/articles/PMC4729691/ /pubmed/26652002 http://dx.doi.org/10.7554/eLife.09460 Text en © 2015, Loh et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Loh, Dawn H Jami, Shekib A Flores, Richard E Truong, Danny Ghiani, Cristina A O’Dell, Thomas J Colwell, Christopher S Misaligned feeding impairs memories |
title | Misaligned feeding impairs memories |
title_full | Misaligned feeding impairs memories |
title_fullStr | Misaligned feeding impairs memories |
title_full_unstemmed | Misaligned feeding impairs memories |
title_short | Misaligned feeding impairs memories |
title_sort | misaligned feeding impairs memories |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729691/ https://www.ncbi.nlm.nih.gov/pubmed/26652002 http://dx.doi.org/10.7554/eLife.09460 |
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