Cargando…

Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases

PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on...

Descripción completa

Detalles Bibliográficos
Autores principales: von Moos, Roger, Body, Jean-Jacques, Egerdie, Blair, Stopeck, Alison, Brown, Janet, Fallowfield, Lesley, Patrick, Donald L., Cleeland, Charles, Damyanov, Danail, Palazzo, Felipe Salvador, Marx, Gavin, Zhou, Ying, Braun, Ada, Balakumaran, Arun, Qian, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729787/
https://www.ncbi.nlm.nih.gov/pubmed/26329397
http://dx.doi.org/10.1007/s00520-015-2908-1
_version_ 1782412293569511424
author von Moos, Roger
Body, Jean-Jacques
Egerdie, Blair
Stopeck, Alison
Brown, Janet
Fallowfield, Lesley
Patrick, Donald L.
Cleeland, Charles
Damyanov, Danail
Palazzo, Felipe Salvador
Marx, Gavin
Zhou, Ying
Braun, Ada
Balakumaran, Arun
Qian, Yi
author_facet von Moos, Roger
Body, Jean-Jacques
Egerdie, Blair
Stopeck, Alison
Brown, Janet
Fallowfield, Lesley
Patrick, Donald L.
Cleeland, Charles
Damyanov, Danail
Palazzo, Felipe Salvador
Marx, Gavin
Zhou, Ying
Braun, Ada
Balakumaran, Arun
Qian, Yi
author_sort von Moos, Roger
collection PubMed
description PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients’ pain, analgesic use, and pain interference with daily functioning. METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm. RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function. CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning.
format Online
Article
Text
id pubmed-4729787
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-47297872016-02-04 Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases von Moos, Roger Body, Jean-Jacques Egerdie, Blair Stopeck, Alison Brown, Janet Fallowfield, Lesley Patrick, Donald L. Cleeland, Charles Damyanov, Danail Palazzo, Felipe Salvador Marx, Gavin Zhou, Ying Braun, Ada Balakumaran, Arun Qian, Yi Support Care Cancer Original Article PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC). The aim of this study was to evaluate the impact of SREs on patients’ pain, analgesic use, and pain interference with daily functioning. METHODS: Data were combined from patients with solid tumors and bone metastases who received denosumab or zoledronic acid across three identically designed phase 3 trials (N = 5543). Pain severity (worst pain) and pain interference were assessed using the Brief Pain Inventory at baseline and each monthly visit. Analgesic use was quantified using the Analgesic Quantification Algorithm. RESULTS: The proportion of patients with moderate/severe pain and strong opioid use generally increased in the 6 months preceding an SRE and remained elevated, while they remained relatively consistent over time in patients without an SRE. Regression analysis indicated that all SRE types were significantly associated with an increased risk of progression to moderate/severe pain and strong opioid use. PF, RB, and SCC were associated with significantly greater risk of pain interference overall. Results were similar for pain interference with emotional well-being. All SRE types were associated with significantly greater risk of pain interference with physical function. CONCLUSIONS: SREs are associated with increased pain and analgesic use in patients with bone metastases. Treatments that prevent SREs may decrease pain and the need for opioid analgesics and reduce the impact of pain on daily functioning. Springer Berlin Heidelberg 2015-09-02 2016 /pmc/articles/PMC4729787/ /pubmed/26329397 http://dx.doi.org/10.1007/s00520-015-2908-1 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
von Moos, Roger
Body, Jean-Jacques
Egerdie, Blair
Stopeck, Alison
Brown, Janet
Fallowfield, Lesley
Patrick, Donald L.
Cleeland, Charles
Damyanov, Danail
Palazzo, Felipe Salvador
Marx, Gavin
Zhou, Ying
Braun, Ada
Balakumaran, Arun
Qian, Yi
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
title Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
title_full Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
title_fullStr Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
title_full_unstemmed Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
title_short Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
title_sort pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729787/
https://www.ncbi.nlm.nih.gov/pubmed/26329397
http://dx.doi.org/10.1007/s00520-015-2908-1
work_keys_str_mv AT vonmoosroger painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT bodyjeanjacques painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT egerdieblair painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT stopeckalison painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT brownjanet painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT fallowfieldlesley painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT patrickdonaldl painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT cleelandcharles painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT damyanovdanail painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT palazzofelipesalvador painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT marxgavin painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT zhouying painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT braunada painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT balakumaranarun painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases
AT qianyi painandanalgesicuseassociatedwithskeletalrelatedeventsinpatientswithadvancedcancerandbonemetastases