Cargando…
Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry
It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This ‘reverse transduction' force production has never been demonstrated experimentally...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729828/ https://www.ncbi.nlm.nih.gov/pubmed/26732830 http://dx.doi.org/10.1038/ncomms10282 |
_version_ | 1782412303165030400 |
---|---|
author | Ren, Tianying He, Wenxuan Barr-Gillespie, Peter G. |
author_facet | Ren, Tianying He, Wenxuan Barr-Gillespie, Peter G. |
author_sort | Ren, Tianying |
collection | PubMed |
description | It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This ‘reverse transduction' force production has never been demonstrated experimentally, however, in the living ear. Here by directly measuring microstructure vibrations inside the cochlear partition using a custom-built interferometer, we demonstrate that electrical stimulation can evoke both fast broadband and slow sharply tuned responses of the reticular lamina, but only a slow tuned response of the basilar membrane. Our results indicate that outer hair cells can generate sufficient force to drive the reticular lamina over all audible frequencies in living cochleae. Contrary to expectations, the cellular force causes a travelling wave rather than an immediate local vibration of the basilar membrane; this travelling wave vibrates in phase with the reticular lamina at the best frequency, and results in maximal vibration at the apical ends of outer hair cells. |
format | Online Article Text |
id | pubmed-4729828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47298282016-03-04 Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry Ren, Tianying He, Wenxuan Barr-Gillespie, Peter G. Nat Commun Article It is generally believed that the remarkable sensitivity and frequency selectivity of mammalian hearing depend on outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea. This ‘reverse transduction' force production has never been demonstrated experimentally, however, in the living ear. Here by directly measuring microstructure vibrations inside the cochlear partition using a custom-built interferometer, we demonstrate that electrical stimulation can evoke both fast broadband and slow sharply tuned responses of the reticular lamina, but only a slow tuned response of the basilar membrane. Our results indicate that outer hair cells can generate sufficient force to drive the reticular lamina over all audible frequencies in living cochleae. Contrary to expectations, the cellular force causes a travelling wave rather than an immediate local vibration of the basilar membrane; this travelling wave vibrates in phase with the reticular lamina at the best frequency, and results in maximal vibration at the apical ends of outer hair cells. Nature Publishing Group 2016-01-06 /pmc/articles/PMC4729828/ /pubmed/26732830 http://dx.doi.org/10.1038/ncomms10282 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Ren, Tianying He, Wenxuan Barr-Gillespie, Peter G. Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry |
title | Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry |
title_full | Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry |
title_fullStr | Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry |
title_full_unstemmed | Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry |
title_short | Reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry |
title_sort | reverse transduction measured in the living cochlea by low-coherence heterodyne interferometry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729828/ https://www.ncbi.nlm.nih.gov/pubmed/26732830 http://dx.doi.org/10.1038/ncomms10282 |
work_keys_str_mv | AT rentianying reversetransductionmeasuredinthelivingcochleabylowcoherenceheterodyneinterferometry AT hewenxuan reversetransductionmeasuredinthelivingcochleabylowcoherenceheterodyneinterferometry AT barrgillespiepeterg reversetransductionmeasuredinthelivingcochleabylowcoherenceheterodyneinterferometry |