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Comparative Anatomy of Phagocytic and Immunological Synapses
The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types. However, growing experimental evidence shows that a very close series of m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729869/ https://www.ncbi.nlm.nih.gov/pubmed/26858721 http://dx.doi.org/10.3389/fimmu.2016.00018 |
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author | Niedergang, Florence Di Bartolo, Vincenzo Alcover, Andrés |
author_facet | Niedergang, Florence Di Bartolo, Vincenzo Alcover, Andrés |
author_sort | Niedergang, Florence |
collection | PubMed |
description | The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types. However, growing experimental evidence shows that a very close series of molecular and cellular events control these two processes. Thus, the tight and dynamic interplay between receptor signaling, actin and microtubule cytoskeleton, and targeted vesicle traffic are all critical features to build functional phagosomes and immunological synapses. Interestingly, both phagocytic cups and immunological synapses display particular spatial and temporal patterns of receptors and signaling molecules, leading to the notion of “phagocytic synapse.” Here, we discuss both types of structures, their organization, and the mechanisms by which they are generated and regulated. |
format | Online Article Text |
id | pubmed-4729869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47298692016-02-08 Comparative Anatomy of Phagocytic and Immunological Synapses Niedergang, Florence Di Bartolo, Vincenzo Alcover, Andrés Front Immunol Immunology The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types. However, growing experimental evidence shows that a very close series of molecular and cellular events control these two processes. Thus, the tight and dynamic interplay between receptor signaling, actin and microtubule cytoskeleton, and targeted vesicle traffic are all critical features to build functional phagosomes and immunological synapses. Interestingly, both phagocytic cups and immunological synapses display particular spatial and temporal patterns of receptors and signaling molecules, leading to the notion of “phagocytic synapse.” Here, we discuss both types of structures, their organization, and the mechanisms by which they are generated and regulated. Frontiers Media S.A. 2016-01-28 /pmc/articles/PMC4729869/ /pubmed/26858721 http://dx.doi.org/10.3389/fimmu.2016.00018 Text en Copyright © 2016 Niedergang, Di Bartolo and Alcover. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Niedergang, Florence Di Bartolo, Vincenzo Alcover, Andrés Comparative Anatomy of Phagocytic and Immunological Synapses |
title | Comparative Anatomy of Phagocytic and Immunological Synapses |
title_full | Comparative Anatomy of Phagocytic and Immunological Synapses |
title_fullStr | Comparative Anatomy of Phagocytic and Immunological Synapses |
title_full_unstemmed | Comparative Anatomy of Phagocytic and Immunological Synapses |
title_short | Comparative Anatomy of Phagocytic and Immunological Synapses |
title_sort | comparative anatomy of phagocytic and immunological synapses |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729869/ https://www.ncbi.nlm.nih.gov/pubmed/26858721 http://dx.doi.org/10.3389/fimmu.2016.00018 |
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