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Animal Models for HIV Cure Research

The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot clear the virus from the infected patient. A cure for HIV-1 is badly needed to stop both the spread of the virus in human...

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Autores principales: Policicchio, Benjamin B., Pandrea, Ivona, Apetrei, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729870/
https://www.ncbi.nlm.nih.gov/pubmed/26858716
http://dx.doi.org/10.3389/fimmu.2016.00012
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author Policicchio, Benjamin B.
Pandrea, Ivona
Apetrei, Cristian
author_facet Policicchio, Benjamin B.
Pandrea, Ivona
Apetrei, Cristian
author_sort Policicchio, Benjamin B.
collection PubMed
description The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot clear the virus from the infected patient. A cure for HIV-1 is badly needed to stop both the spread of the virus in human populations and disease progression in infected individuals. A safe and effective cure strategy for human immunodeficiency virus (HIV) infection will require multiple tools, and appropriate animal models are tools that are central to cure research. An ideal animal model should recapitulate the essential aspects of HIV pathogenesis and associated immune responses, while permitting invasive studies, thus allowing a thorough evaluation of strategies aimed at reducing the size of the reservoir (functional cure) or eliminating the reservoir altogether (sterilizing cure). Since there is no perfect animal model for cure research, multiple models have been tailored and tested to address specific quintessential questions of virus persistence and eradication. The development of new non-human primate and mouse models, along with a certain interest in the feline model, has the potential to fuel cure research. In this review, we highlight the major animal models currently utilized for cure research and the contributions of each model to this goal.
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spelling pubmed-47298702016-02-08 Animal Models for HIV Cure Research Policicchio, Benjamin B. Pandrea, Ivona Apetrei, Cristian Front Immunol Immunology The HIV-1/AIDS pandemic continues to spread unabated worldwide, and no vaccine exists within our grasp. Effective antiretroviral therapy (ART) has been developed, but ART cannot clear the virus from the infected patient. A cure for HIV-1 is badly needed to stop both the spread of the virus in human populations and disease progression in infected individuals. A safe and effective cure strategy for human immunodeficiency virus (HIV) infection will require multiple tools, and appropriate animal models are tools that are central to cure research. An ideal animal model should recapitulate the essential aspects of HIV pathogenesis and associated immune responses, while permitting invasive studies, thus allowing a thorough evaluation of strategies aimed at reducing the size of the reservoir (functional cure) or eliminating the reservoir altogether (sterilizing cure). Since there is no perfect animal model for cure research, multiple models have been tailored and tested to address specific quintessential questions of virus persistence and eradication. The development of new non-human primate and mouse models, along with a certain interest in the feline model, has the potential to fuel cure research. In this review, we highlight the major animal models currently utilized for cure research and the contributions of each model to this goal. Frontiers Media S.A. 2016-01-28 /pmc/articles/PMC4729870/ /pubmed/26858716 http://dx.doi.org/10.3389/fimmu.2016.00012 Text en Copyright © 2016 Policicchio, Pandrea and Apetrei. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Policicchio, Benjamin B.
Pandrea, Ivona
Apetrei, Cristian
Animal Models for HIV Cure Research
title Animal Models for HIV Cure Research
title_full Animal Models for HIV Cure Research
title_fullStr Animal Models for HIV Cure Research
title_full_unstemmed Animal Models for HIV Cure Research
title_short Animal Models for HIV Cure Research
title_sort animal models for hiv cure research
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729870/
https://www.ncbi.nlm.nih.gov/pubmed/26858716
http://dx.doi.org/10.3389/fimmu.2016.00012
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