mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

Mechanistic target of rapamycin complex 1 (mTORC1), defined by the presence of Raptor, is an evolutionarily conserved and nutrient-sensitive regulator of cellular growth and other metabolic processes. To date, all known functions of Raptor involve its scaffolding mTOR kinase with substrate. Here we...

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Detalles Bibliográficos
Autores principales: Kim, KyeongJin, Qiang, Li, Hayden, Matthew S., Sparling, David P., Purcell, Nicole H., Pajvani, Utpal B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729872/
https://www.ncbi.nlm.nih.gov/pubmed/26743335
http://dx.doi.org/10.1038/ncomms10255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729872/
https://www.ncbi.nlm.nih.gov/pubmed/26743335
http://dx.doi.org/10.1038/ncomms10255

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