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Replication landscape of the human genome

Despite intense investigation, human replication origins and termini remain elusive. Existing data have shown strong discrepancies. Here we sequenced highly purified Okazaki fragments from two cell types and, for the first time, quantitated replication fork directionality and delineated initiation a...

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Detalles Bibliográficos
Autores principales: Petryk, Nataliya, Kahli, Malik, d'Aubenton-Carafa, Yves, Jaszczyszyn, Yan, Shen, Yimin, Silvain, Maud, Thermes, Claude, Chen, Chun-Long, Hyrien, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729899/
https://www.ncbi.nlm.nih.gov/pubmed/26751768
http://dx.doi.org/10.1038/ncomms10208