Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats

Renal artery stenosis is frequently associated with resistant hypertension, which is defined as failure to normalize blood pressure (BP) even when combined drugs are used. Inhibition of PDE5 by sildenafil has been shown to increase endothelial function and decrease blood pressure in experimental mod...

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Autores principales: Cavalcanti, Clênia de Oliveira, Alves, Rafael R., de Oliveira, Alessandro L., Cruz, Josiane de Campos, de França-Silva, Maria do Socorro, Braga, Valdir de Andrade, Balarini, Camille de Moura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729906/
https://www.ncbi.nlm.nih.gov/pubmed/26858657
http://dx.doi.org/10.3389/fphys.2016.00015
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author Cavalcanti, Clênia de Oliveira
Alves, Rafael R.
de Oliveira, Alessandro L.
Cruz, Josiane de Campos
de França-Silva, Maria do Socorro
Braga, Valdir de Andrade
Balarini, Camille de Moura
author_facet Cavalcanti, Clênia de Oliveira
Alves, Rafael R.
de Oliveira, Alessandro L.
Cruz, Josiane de Campos
de França-Silva, Maria do Socorro
Braga, Valdir de Andrade
Balarini, Camille de Moura
author_sort Cavalcanti, Clênia de Oliveira
collection PubMed
description Renal artery stenosis is frequently associated with resistant hypertension, which is defined as failure to normalize blood pressure (BP) even when combined drugs are used. Inhibition of PDE5 by sildenafil has been shown to increase endothelial function and decrease blood pressure in experimental models. However, no available study evaluated the baroreflex sensitivity nor autonomic balance in renovascular hypertensive rats treated with sildenafil. In a translational medicine perspective, our hypothesis is that sildenafil could improve autonomic imbalance and baroreflex sensitivity, contributing to lower blood pressure. Renovascular hypertensive 2-kidney-1-clip (2K1C) and sham rats were treated with sildenafil (45 mg/Kg/day) during 7 days. At the end of treatment, BP and heart rate (HR) were recorded in conscious rats after a 24-h-recovery period. Spontaneous and drug-induced baroreflex sensitivity and autonomic tone were evaluated; in addition, lipid peroxidation was measured in plasma samples. Treatment was efficient in increasing both spontaneous and induced baroreflex sensitivity in treated hypertensive animals. Inhibition of PDE5 was also capable of ameliorating autonomic imbalance in 2K1C rats and decreasing systemic oxidative stress. Taken together, these beneficial effects resulted in significant reductions in BP without affecting HR. We suggest that sildenafil could be considered as a promising alternative to treat resistant hypertension.
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spelling pubmed-47299062016-02-08 Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats Cavalcanti, Clênia de Oliveira Alves, Rafael R. de Oliveira, Alessandro L. Cruz, Josiane de Campos de França-Silva, Maria do Socorro Braga, Valdir de Andrade Balarini, Camille de Moura Front Physiol Physiology Renal artery stenosis is frequently associated with resistant hypertension, which is defined as failure to normalize blood pressure (BP) even when combined drugs are used. Inhibition of PDE5 by sildenafil has been shown to increase endothelial function and decrease blood pressure in experimental models. However, no available study evaluated the baroreflex sensitivity nor autonomic balance in renovascular hypertensive rats treated with sildenafil. In a translational medicine perspective, our hypothesis is that sildenafil could improve autonomic imbalance and baroreflex sensitivity, contributing to lower blood pressure. Renovascular hypertensive 2-kidney-1-clip (2K1C) and sham rats were treated with sildenafil (45 mg/Kg/day) during 7 days. At the end of treatment, BP and heart rate (HR) were recorded in conscious rats after a 24-h-recovery period. Spontaneous and drug-induced baroreflex sensitivity and autonomic tone were evaluated; in addition, lipid peroxidation was measured in plasma samples. Treatment was efficient in increasing both spontaneous and induced baroreflex sensitivity in treated hypertensive animals. Inhibition of PDE5 was also capable of ameliorating autonomic imbalance in 2K1C rats and decreasing systemic oxidative stress. Taken together, these beneficial effects resulted in significant reductions in BP without affecting HR. We suggest that sildenafil could be considered as a promising alternative to treat resistant hypertension. Frontiers Media S.A. 2016-01-28 /pmc/articles/PMC4729906/ /pubmed/26858657 http://dx.doi.org/10.3389/fphys.2016.00015 Text en Copyright © 2016 Cavalcanti, Alves, Oliveira, Cruz, França-Silva, Braga and Balarini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Cavalcanti, Clênia de Oliveira
Alves, Rafael R.
de Oliveira, Alessandro L.
Cruz, Josiane de Campos
de França-Silva, Maria do Socorro
Braga, Valdir de Andrade
Balarini, Camille de Moura
Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats
title Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats
title_full Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats
title_fullStr Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats
title_full_unstemmed Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats
title_short Inhibition of PDE5 Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats
title_sort inhibition of pde5 restores depressed baroreflex sensitivity in renovascular hypertensive rats
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729906/
https://www.ncbi.nlm.nih.gov/pubmed/26858657
http://dx.doi.org/10.3389/fphys.2016.00015
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