Cargando…

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This p...

Descripción completa

Detalles Bibliográficos
Autores principales: Laurent, Victor, Guérard, Adrien, Mazerolles, Catherine, Le Gonidec, Sophie, Toulet, Aurélie, Nieto, Laurence, Zaidi, Falek, Majed, Bilal, Garandeau, David, Socrier, Youri, Golzio, Muriel, Cadoudal, Thomas, Chaoui, Karima, Dray, Cedric, Monsarrat, Bernard, Schiltz, Odile, Wang, Yuan Yuan, Couderc, Bettina, Valet, Philippe, Malavaud, Bernard, Muller, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729927/
https://www.ncbi.nlm.nih.gov/pubmed/26756352
http://dx.doi.org/10.1038/ncomms10230
_version_ 1782412322492383232
author Laurent, Victor
Guérard, Adrien
Mazerolles, Catherine
Le Gonidec, Sophie
Toulet, Aurélie
Nieto, Laurence
Zaidi, Falek
Majed, Bilal
Garandeau, David
Socrier, Youri
Golzio, Muriel
Cadoudal, Thomas
Chaoui, Karima
Dray, Cedric
Monsarrat, Bernard
Schiltz, Odile
Wang, Yuan Yuan
Couderc, Bettina
Valet, Philippe
Malavaud, Bernard
Muller, Catherine
author_facet Laurent, Victor
Guérard, Adrien
Mazerolles, Catherine
Le Gonidec, Sophie
Toulet, Aurélie
Nieto, Laurence
Zaidi, Falek
Majed, Bilal
Garandeau, David
Socrier, Youri
Golzio, Muriel
Cadoudal, Thomas
Chaoui, Karima
Dray, Cedric
Monsarrat, Bernard
Schiltz, Odile
Wang, Yuan Yuan
Couderc, Bettina
Valet, Philippe
Malavaud, Bernard
Muller, Catherine
author_sort Laurent, Victor
collection PubMed
description Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells. In obesity, higher secretion of CCL7 by adipocytes facilitates extraprostatic extension. The observed increase in migration associated with obesity is totally abrogated when the CCR3/CCL7 axis is inhibited. In human prostate cancer tumours, expression of the CCR3 receptor is associated with the occurrence of aggressive disease with extended local dissemination and a higher risk of biochemical recurrence, highlighting the potential benefit of CCR3 antagonists in the treatment of prostate cancer.
format Online
Article
Text
id pubmed-4729927
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-47299272016-03-04 Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity Laurent, Victor Guérard, Adrien Mazerolles, Catherine Le Gonidec, Sophie Toulet, Aurélie Nieto, Laurence Zaidi, Falek Majed, Bilal Garandeau, David Socrier, Youri Golzio, Muriel Cadoudal, Thomas Chaoui, Karima Dray, Cedric Monsarrat, Bernard Schiltz, Odile Wang, Yuan Yuan Couderc, Bettina Valet, Philippe Malavaud, Bernard Muller, Catherine Nat Commun Article Obesity favours the occurrence of locally disseminated prostate cancer in the periprostatic adipose tissue (PPAT) surrounding the prostate gland. Here we show that adipocytes from PPAT support the directed migration of prostate cancer cells and that this event is strongly promoted by obesity. This process is dependent on the secretion of the chemokine CCL7 by adipocytes, which diffuses from PPAT to the peripheral zone of the prostate, stimulating the migration of CCR3 expressing tumour cells. In obesity, higher secretion of CCL7 by adipocytes facilitates extraprostatic extension. The observed increase in migration associated with obesity is totally abrogated when the CCR3/CCL7 axis is inhibited. In human prostate cancer tumours, expression of the CCR3 receptor is associated with the occurrence of aggressive disease with extended local dissemination and a higher risk of biochemical recurrence, highlighting the potential benefit of CCR3 antagonists in the treatment of prostate cancer. Nature Publishing Group 2016-01-12 /pmc/articles/PMC4729927/ /pubmed/26756352 http://dx.doi.org/10.1038/ncomms10230 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Laurent, Victor
Guérard, Adrien
Mazerolles, Catherine
Le Gonidec, Sophie
Toulet, Aurélie
Nieto, Laurence
Zaidi, Falek
Majed, Bilal
Garandeau, David
Socrier, Youri
Golzio, Muriel
Cadoudal, Thomas
Chaoui, Karima
Dray, Cedric
Monsarrat, Bernard
Schiltz, Odile
Wang, Yuan Yuan
Couderc, Bettina
Valet, Philippe
Malavaud, Bernard
Muller, Catherine
Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
title Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
title_full Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
title_fullStr Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
title_full_unstemmed Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
title_short Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
title_sort periprostatic adipocytes act as a driving force for prostate cancer progression in obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729927/
https://www.ncbi.nlm.nih.gov/pubmed/26756352
http://dx.doi.org/10.1038/ncomms10230
work_keys_str_mv AT laurentvictor periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT guerardadrien periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT mazerollescatherine periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT legonidecsophie periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT touletaurelie periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT nietolaurence periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT zaidifalek periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT majedbilal periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT garandeaudavid periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT socrieryouri periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT golziomuriel periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT cadoudalthomas periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT chaouikarima periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT draycedric periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT monsarratbernard periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT schiltzodile periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT wangyuanyuan periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT coudercbettina periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT valetphilippe periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT malavaudbernard periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity
AT mullercatherine periprostaticadipocytesactasadrivingforceforprostatecancerprogressioninobesity