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Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study

Compound infantile hemangiomas (IHs) are problematic and usually require intervention. This retrospective study aimed to introduce a combined therapy of oral propranolol and topical timolol, and evaluate its efficacy and safety. Eighty-nine infants with compound IHs were treated with oral propranolo...

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Autores principales: Ge, Jing, Zheng, Jiawei, Zhang, Ling, Yuan, Weien, Zhao, Haiguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730155/
https://www.ncbi.nlm.nih.gov/pubmed/26819072
http://dx.doi.org/10.1038/srep19765
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author Ge, Jing
Zheng, Jiawei
Zhang, Ling
Yuan, Weien
Zhao, Haiguang
author_facet Ge, Jing
Zheng, Jiawei
Zhang, Ling
Yuan, Weien
Zhao, Haiguang
author_sort Ge, Jing
collection PubMed
description Compound infantile hemangiomas (IHs) are problematic and usually require intervention. This retrospective study aimed to introduce a combined therapy of oral propranolol and topical timolol, and evaluate its efficacy and safety. Eighty-nine infants with compound IHs were treated with oral propranolol 2 mg/kg/day divided 2 times per day and timolol maleate 0.5% gel 3 times per day, for at least 3 months. Two observers evaluated the hemangioma independently at 0, 1, 3, 6, 9 months after the initiation of treatment. Changes in the hemangioma score values were evaluated using paired t test. Rebound growth and adverse effects were recorded. After treatment was completed, this combined therapy achieved clinical response in 100% of the patients (89/89). Significant positive effects were demonstrated at 1, 3, 6 months (p < 0.001), but not obvious after 6 months (p = 0.06). The response of IHs to the therapy was depending on the age at initial treatment. The average treatment duration was 6.48 (5.77–7.19) months. One patient (1.1%) relapsed after cessation of 6-month treatment, and 7 children (7.8%) developed side effects. Our study suggested that oral propranolol combined with topical timolol treatment is very effective and well-tolerated for compound IHs, which can be used as a first line treatment.
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spelling pubmed-47301552016-02-03 Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study Ge, Jing Zheng, Jiawei Zhang, Ling Yuan, Weien Zhao, Haiguang Sci Rep Article Compound infantile hemangiomas (IHs) are problematic and usually require intervention. This retrospective study aimed to introduce a combined therapy of oral propranolol and topical timolol, and evaluate its efficacy and safety. Eighty-nine infants with compound IHs were treated with oral propranolol 2 mg/kg/day divided 2 times per day and timolol maleate 0.5% gel 3 times per day, for at least 3 months. Two observers evaluated the hemangioma independently at 0, 1, 3, 6, 9 months after the initiation of treatment. Changes in the hemangioma score values were evaluated using paired t test. Rebound growth and adverse effects were recorded. After treatment was completed, this combined therapy achieved clinical response in 100% of the patients (89/89). Significant positive effects were demonstrated at 1, 3, 6 months (p < 0.001), but not obvious after 6 months (p = 0.06). The response of IHs to the therapy was depending on the age at initial treatment. The average treatment duration was 6.48 (5.77–7.19) months. One patient (1.1%) relapsed after cessation of 6-month treatment, and 7 children (7.8%) developed side effects. Our study suggested that oral propranolol combined with topical timolol treatment is very effective and well-tolerated for compound IHs, which can be used as a first line treatment. Nature Publishing Group 2016-01-28 /pmc/articles/PMC4730155/ /pubmed/26819072 http://dx.doi.org/10.1038/srep19765 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ge, Jing
Zheng, Jiawei
Zhang, Ling
Yuan, Weien
Zhao, Haiguang
Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study
title Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study
title_full Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study
title_fullStr Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study
title_full_unstemmed Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study
title_short Oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study
title_sort oral propranolol combined with topical timolol for compound infantile hemangiomas: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730155/
https://www.ncbi.nlm.nih.gov/pubmed/26819072
http://dx.doi.org/10.1038/srep19765
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