Cargando…

Cytotoxic Rocaglate Derivatives from Leaves of Aglaia perviridis

Rocaglates are a series of structurally complex secondary metabolites with considerable cytotoxicity that have been isolated from plants of the Aglaia genus (Meliaceae). A new rocaglate (aglapervirisin A, 1) and its eight new biosynthetic precursors of rocaglate (aglapervirisins B-J, 2–9) together w...

Descripción completa

Detalles Bibliográficos
Autores principales:	An, Fa-Liang, Wang, Xiao-Bing, Wang, Hui, Li, Zhong-Rui, Yang, Ming-Hua, Luo, Jun, Kong, Ling-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730247/ https://www.ncbi.nlm.nih.gov/pubmed/26818797 http://dx.doi.org/10.1038/srep20045

Ejemplares similares

A parasitic fungus employs mutated eIF4A to survive on rocaglate-synthesizing Aglaia plants
por: Chen, Mingming, et al.
Publicado: (2023)

Cabraleahydroxylactone from the leaves of Aglaia exima
por: Loong, Xe Min, et al.
Publicado: (2010)

A phenolic ester from Aglaia loheri leaves reveals cytotoxicity towards sensitive and multidrug-resistant cancer cells
por: Dapat, Else, et al.
Publicado: (2013)

PHARMACOLOGICAL INVESTIGATIONS ON AGLAIA ROXBURGHIANA (W. &.A) MIQ. VAR. BEDDOMEI LEAVES
por: Janaki, S., et al.
Publicado: (1998)

Fine-tuning of macrophage activation using synthetic rocaglate derivatives
por: Bhattacharya, Bidisha, et al.
Publicado: (2016)

The complete chloroplast genome sequence of Aglaia odorata
por: Zhang, Jinfeng, et al.
Publicado: (2020)

Cycloart-24-ene-3β,26-diol from the leaves of Aglaia exima
por: Awang, Khalijah, et al.
Publicado: (2010)

Dammarane-Type Triterpenoid from the Stem Bark of Aglaia elliptica (Meliaceae) and Its Cytotoxic Activities
por: Farabi, Kindi, et al.
Publicado: (2022)

The Cytotoxic Activity of Dammarane-Type Triterpenoids Isolated from the Stem Bark of Aglaia cucullata (Meliaceae)
por: Purnama, et al.
Publicado: (2023)

Cytotoxic and Apoptotic Activity of Aglaforbesin Derivative Isolated from Aglaia loheri Merr. on HCT116 Human Colorectal Cancer Cells
por: Abalos, Norielyn N., et al.
Publicado: (2021)

Pharmacognostical Studiies on Aglaia Roxburghiana Miq. Var. Beddomei
por: Sasikala, E., et al.
Publicado: (1999)

A forward genetic screen identifies modifiers of rocaglate responsiveness
por: Shen, Leo, et al.
Publicado: (2021)

Whole-Genome DNA Methylation Analysis in Brassica rapa subsp. perviridis in Response to Albugo candida Infection
por: Tirnaz, Soodeh, et al.
Publicado: (2022)

Targeting Translation Initiation by Synthetic Rocaglates for Treating MYC-driven Lymphomas
por: Zhang, Xuan, et al.
Publicado: (2019)

Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone
por: Lajkiewicz, Neil J., et al.
Publicado: (2014)

Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
por: Chatterjee, Sujoy, et al.
Publicado: (2021)

Proteomics reveal extensive translatome reprogramming and biomarkers of rocaglate toxicity and resistance in cancer
por: Ho, J.J.D., et al.
Publicado: (2020)

The rocaglate CR-31-B (−) inhibits SARS-CoV-2 replication at non-cytotoxic, low nanomolar concentrations in vitro and ex vivo
por: Müller, Christin, et al.
Publicado: (2021)

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
por: Chu, Jennifer, et al.
Publicado: (2020)

Comparing the Effects of Rocaglates on Energy Metabolism and Immune Modulation on Cells of the Human Immune System
por: Schiffmann, Susanne, et al.
Publicado: (2023)

Two new species and a new species record of Aglaia (Meliaceae) from Indonesia
por: Pannell, Caroline M., et al.
Publicado: (2020)

Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates
por: Obermann, Wiebke, et al.
Publicado: (2023)

Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
por: Iwasaki, Shintaro, et al.
Publicado: (2016)

Inhibition of nasopharyngeal carcinoma cell proliferation and synergism of cisplatin with silvestrol and episilvestrol isolated from Aglaia stellatopilosa
por: DAKER, MAELINDA, et al.
Publicado: (2016)

Comparative phytochemistry of flavaglines (= rocaglamides), a group of highly bioactive flavolignans from Aglaia species (Meliaceae)
por: Greger, Harald
Publicado: (2021)

New Formyl Phloroglucinol Meroterpenoids from the Leaves of Eucalyptus robusta
por: Shang, Zhi-Chun, et al.
Publicado: (2016)

Triterpenoids from Aglaia abbreviata exert cytotoxicity and multidrug resistant reversal effect in MCF-7/ADM cells via reactive oxygen species induction and P-glycoprotein inhibition
por: Cen, Juan, et al.
Publicado: (2017)

(20S)-Dammar-24-ene-3β,20-diol monohydrate from the bark of Aglaia exima (Meliaceae)
por: Safariari, Agus, et al.
Publicado: (2012)

3-epi-Dammarenediol II 1.075 hydrate: a dammarane triterpene from the bark of Aglaia eximia
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

Seven new cytotoxic phenylspirodrimane derivatives from the endophytic fungus Stachybotrys chartarum
por: Zhang, Hong, et al.
Publicado: (2019)

Evaluation of the enhancement of photosynthetic rate in a komatsuna (Brassica rapa L. var. perviridis) canopy with upward lighting using an optical simulation in a plant factory with artificial light
por: Saito, Kota, et al.
Publicado: (2023)

Comparison of broad-spectrum antiviral activities of the synthetic rocaglate CR-31-B (−) and the eIF4A-inhibitor Silvestrol
por: Müller, Christin, et al.
Publicado: (2020)

Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris
por: Iyer, Kali R., et al.
Publicado: (2020)

Treatment resistance analysis reveals GLUT‐1‐mediated glucose uptake as a major target of synthetic rocaglates in cancer cells
por: Sieber‐Frank, Julia, et al.
Publicado: (2021)

Rocaglates as Antivirals: Comparing the Effects on Viral Resistance, Anti-Coronaviral Activity, RNA-Clamping on eIF4A and Immune Cell Toxicity
por: Obermann, Wiebke, et al.
Publicado: (2022)

Synthesis, Characterization and Cytotoxicity of New Rotundic Acid Derivatives
por: He, Yu-Fang, et al.
Publicado: (2012)

Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line
por: Leong, Kok Hoong, et al.
Publicado: (2016)

Compared with the intake of commercial vegetable juice, the intake of fresh fruit and komatsuna (Brassica rapa L. var. perviridis) juice mixture reduces serum cholesterol in middle-aged men: a randomized controlled pilot study
por: Aiso, Izumi, et al.
Publicado: (2014)

Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates—A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics
por: Taroncher-Oldenburg, Gaspar, et al.
Publicado: (2021)

Cytotoxic and Anti-Inflammatory Triterpenoids in the Vines and Leaves of Momordica charantia
por: Chou, Mei-Chia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3jhpmfv5bc54gjdj9a9r980ghm