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Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity
Recently, an increasing number of studies on natural antisense transcripts have been reported, especially regarding their classification, temporal and spatial expression patterns, regulatory functions and mechanisms. It is well established that natural antisense transcripts are produced from the str...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730256/ https://www.ncbi.nlm.nih.gov/pubmed/26703594 http://dx.doi.org/10.3390/ijms17010009 |
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author | Lin, Shudai Zhang, Li Luo, Wen Zhang, Xiquan |
author_facet | Lin, Shudai Zhang, Li Luo, Wen Zhang, Xiquan |
author_sort | Lin, Shudai |
collection | PubMed |
description | Recently, an increasing number of studies on natural antisense transcripts have been reported, especially regarding their classification, temporal and spatial expression patterns, regulatory functions and mechanisms. It is well established that natural antisense transcripts are produced from the strand opposite to the strand encoding a protein. Despite the pivotal roles of natural antisense transcripts in regulating the expression of target genes, the transcriptional mechanisms initiated by antisense promoters (ASPs) remain unknown. To date, nearly all of the studies conducted on this topic have focused on the ASP of a single gene of interest, whereas no study has systematically analyzed the locations of ASPs in the genome, ASP activity, or factors influencing this activity. This review focuses on elaborating on and summarizing the characteristics of ASPs to extend our knowledge about the mechanisms of antisense transcript initiation. |
format | Online Article Text |
id | pubmed-4730256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47302562016-02-11 Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity Lin, Shudai Zhang, Li Luo, Wen Zhang, Xiquan Int J Mol Sci Review Recently, an increasing number of studies on natural antisense transcripts have been reported, especially regarding their classification, temporal and spatial expression patterns, regulatory functions and mechanisms. It is well established that natural antisense transcripts are produced from the strand opposite to the strand encoding a protein. Despite the pivotal roles of natural antisense transcripts in regulating the expression of target genes, the transcriptional mechanisms initiated by antisense promoters (ASPs) remain unknown. To date, nearly all of the studies conducted on this topic have focused on the ASP of a single gene of interest, whereas no study has systematically analyzed the locations of ASPs in the genome, ASP activity, or factors influencing this activity. This review focuses on elaborating on and summarizing the characteristics of ASPs to extend our knowledge about the mechanisms of antisense transcript initiation. MDPI 2015-12-23 /pmc/articles/PMC4730256/ /pubmed/26703594 http://dx.doi.org/10.3390/ijms17010009 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lin, Shudai Zhang, Li Luo, Wen Zhang, Xiquan Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity |
title | Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity |
title_full | Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity |
title_fullStr | Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity |
title_full_unstemmed | Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity |
title_short | Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity |
title_sort | characteristics of antisense transcript promoters and the regulation of their activity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730256/ https://www.ncbi.nlm.nih.gov/pubmed/26703594 http://dx.doi.org/10.3390/ijms17010009 |
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