Research Advances on Pathways of Nickel-Induced Apoptosis

High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitoc...

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Autores principales: Guo, Hongrui, Chen, Lian, Cui, Hengmin, Peng, Xi, Fang, Jing, Zuo, Zhicai, Deng, Junliang, Wang, Xun, Wu, Bangyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730257/
https://www.ncbi.nlm.nih.gov/pubmed/26703593
http://dx.doi.org/10.3390/ijms17010010
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author Guo, Hongrui
Chen, Lian
Cui, Hengmin
Peng, Xi
Fang, Jing
Zuo, Zhicai
Deng, Junliang
Wang, Xun
Wu, Bangyuan
author_facet Guo, Hongrui
Chen, Lian
Cui, Hengmin
Peng, Xi
Fang, Jing
Zuo, Zhicai
Deng, Junliang
Wang, Xun
Wu, Bangyuan
author_sort Guo, Hongrui
collection PubMed
description High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitochondria, endoplasmic reticulum (ER), Fas, and c-Myc participate in Ni-induced cell apoptosis. However, the exact mechanism of apoptosis caused by Ni is still unclear. Understanding the mechanism of Ni-induced apoptosis may help in designing measures to prevent Ni toxicity.
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spelling pubmed-47302572016-02-11 Research Advances on Pathways of Nickel-Induced Apoptosis Guo, Hongrui Chen, Lian Cui, Hengmin Peng, Xi Fang, Jing Zuo, Zhicai Deng, Junliang Wang, Xun Wu, Bangyuan Int J Mol Sci Review High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitochondria, endoplasmic reticulum (ER), Fas, and c-Myc participate in Ni-induced cell apoptosis. However, the exact mechanism of apoptosis caused by Ni is still unclear. Understanding the mechanism of Ni-induced apoptosis may help in designing measures to prevent Ni toxicity. MDPI 2015-12-23 /pmc/articles/PMC4730257/ /pubmed/26703593 http://dx.doi.org/10.3390/ijms17010010 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Guo, Hongrui
Chen, Lian
Cui, Hengmin
Peng, Xi
Fang, Jing
Zuo, Zhicai
Deng, Junliang
Wang, Xun
Wu, Bangyuan
Research Advances on Pathways of Nickel-Induced Apoptosis
title Research Advances on Pathways of Nickel-Induced Apoptosis
title_full Research Advances on Pathways of Nickel-Induced Apoptosis
title_fullStr Research Advances on Pathways of Nickel-Induced Apoptosis
title_full_unstemmed Research Advances on Pathways of Nickel-Induced Apoptosis
title_short Research Advances on Pathways of Nickel-Induced Apoptosis
title_sort research advances on pathways of nickel-induced apoptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730257/
https://www.ncbi.nlm.nih.gov/pubmed/26703593
http://dx.doi.org/10.3390/ijms17010010
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