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PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730267/ https://www.ncbi.nlm.nih.gov/pubmed/26712739 http://dx.doi.org/10.3390/ijms17010020 |
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author | Tain, You-Lin Hsu, Chien-Ning Chan, Julie Y. H. |
author_facet | Tain, You-Lin Hsu, Chien-Ning Chan, Julie Y. H. |
author_sort | Tain, You-Lin |
collection | PubMed |
description | Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to hypertension and metabolic syndrome. All three members of PPARs, PPARα, PPARβ/δ, and PPARγ, are expressed in the kidney and involved in blood pressure control. This review provides an overview of potential clinical applications of targeting on the PPARs in the kidney to prevent programmed hypertension and metabolic syndrome, with an emphasis on the following areas: mechanistic insights to interpret programmed hypertension; the link between the PPARs, nutritional insults, and programmed hypertension and metabolic syndrome; the impact of PPAR signaling pathway in a maternal high-fructose model; and current experimental studies on early intervention by PPAR modulators to prevent programmed hypertension and metabolic syndrome. Animal studies employing a reprogramming strategy via targeting PPARs to prevent hypertension have demonstrated interesting results. It is critical that the observed effects on developmental reprogramming in animal models are replicated in human studies, to halt the globally-growing epidemic of metabolic syndrome-related diseases. |
format | Online Article Text |
id | pubmed-4730267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-47302672016-02-11 PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome Tain, You-Lin Hsu, Chien-Ning Chan, Julie Y. H. Int J Mol Sci Review Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to hypertension and metabolic syndrome. All three members of PPARs, PPARα, PPARβ/δ, and PPARγ, are expressed in the kidney and involved in blood pressure control. This review provides an overview of potential clinical applications of targeting on the PPARs in the kidney to prevent programmed hypertension and metabolic syndrome, with an emphasis on the following areas: mechanistic insights to interpret programmed hypertension; the link between the PPARs, nutritional insults, and programmed hypertension and metabolic syndrome; the impact of PPAR signaling pathway in a maternal high-fructose model; and current experimental studies on early intervention by PPAR modulators to prevent programmed hypertension and metabolic syndrome. Animal studies employing a reprogramming strategy via targeting PPARs to prevent hypertension have demonstrated interesting results. It is critical that the observed effects on developmental reprogramming in animal models are replicated in human studies, to halt the globally-growing epidemic of metabolic syndrome-related diseases. MDPI 2015-12-24 /pmc/articles/PMC4730267/ /pubmed/26712739 http://dx.doi.org/10.3390/ijms17010020 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tain, You-Lin Hsu, Chien-Ning Chan, Julie Y. H. PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome |
title | PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome |
title_full | PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome |
title_fullStr | PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome |
title_full_unstemmed | PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome |
title_short | PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome |
title_sort | ppars link early life nutritional insults to later programmed hypertension and metabolic syndrome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730267/ https://www.ncbi.nlm.nih.gov/pubmed/26712739 http://dx.doi.org/10.3390/ijms17010020 |
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