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PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome

Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to...

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Detalles Bibliográficos
Autores principales: Tain, You-Lin, Hsu, Chien-Ning, Chan, Julie Y. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730267/
https://www.ncbi.nlm.nih.gov/pubmed/26712739
http://dx.doi.org/10.3390/ijms17010020
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author Tain, You-Lin
Hsu, Chien-Ning
Chan, Julie Y. H.
author_facet Tain, You-Lin
Hsu, Chien-Ning
Chan, Julie Y. H.
author_sort Tain, You-Lin
collection PubMed
description Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to hypertension and metabolic syndrome. All three members of PPARs, PPARα, PPARβ/δ, and PPARγ, are expressed in the kidney and involved in blood pressure control. This review provides an overview of potential clinical applications of targeting on the PPARs in the kidney to prevent programmed hypertension and metabolic syndrome, with an emphasis on the following areas: mechanistic insights to interpret programmed hypertension; the link between the PPARs, nutritional insults, and programmed hypertension and metabolic syndrome; the impact of PPAR signaling pathway in a maternal high-fructose model; and current experimental studies on early intervention by PPAR modulators to prevent programmed hypertension and metabolic syndrome. Animal studies employing a reprogramming strategy via targeting PPARs to prevent hypertension have demonstrated interesting results. It is critical that the observed effects on developmental reprogramming in animal models are replicated in human studies, to halt the globally-growing epidemic of metabolic syndrome-related diseases.
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spelling pubmed-47302672016-02-11 PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome Tain, You-Lin Hsu, Chien-Ning Chan, Julie Y. H. Int J Mol Sci Review Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to hypertension and metabolic syndrome. All three members of PPARs, PPARα, PPARβ/δ, and PPARγ, are expressed in the kidney and involved in blood pressure control. This review provides an overview of potential clinical applications of targeting on the PPARs in the kidney to prevent programmed hypertension and metabolic syndrome, with an emphasis on the following areas: mechanistic insights to interpret programmed hypertension; the link between the PPARs, nutritional insults, and programmed hypertension and metabolic syndrome; the impact of PPAR signaling pathway in a maternal high-fructose model; and current experimental studies on early intervention by PPAR modulators to prevent programmed hypertension and metabolic syndrome. Animal studies employing a reprogramming strategy via targeting PPARs to prevent hypertension have demonstrated interesting results. It is critical that the observed effects on developmental reprogramming in animal models are replicated in human studies, to halt the globally-growing epidemic of metabolic syndrome-related diseases. MDPI 2015-12-24 /pmc/articles/PMC4730267/ /pubmed/26712739 http://dx.doi.org/10.3390/ijms17010020 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tain, You-Lin
Hsu, Chien-Ning
Chan, Julie Y. H.
PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
title PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
title_full PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
title_fullStr PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
title_full_unstemmed PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
title_short PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
title_sort ppars link early life nutritional insults to later programmed hypertension and metabolic syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730267/
https://www.ncbi.nlm.nih.gov/pubmed/26712739
http://dx.doi.org/10.3390/ijms17010020
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